Galactose absorption after oral administration of lactose in neonates.
Galactose absorption after oral administration of lactose in neonates.
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新生儿口服乳糖后的半乳糖吸收。
DOI：
10.3177/jnsv.35.441
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发表时间：
1989
影响因子：
1.6
通讯作者：
M. Hayashi
中科院分区：
文献类型：
--
作者：
R. Okamoto;M. Mino;M. Hayashi
1.在婴儿和儿童中进行乳糖耐量试验。大多数婴儿对血清葡萄糖升高表现出良好的反应，而2岁以上儿童的反应较差。在这项测试中，血清半乳糖通常是不可检测的，即使在良好的反应。2.在新生儿中同时加载恒定量的半乳糖和不同量的葡萄糖后，血清半乳糖水平的升高程度随着葡萄糖量的增加而降低，并且加载等量的半乳糖和葡萄糖导致血清半乳糖水平没有升高。3.在一个6岁的半乳糖血症的儿童，血清半乳糖水平显着和持续升高后，乳糖负荷。4.新生儿经半乳糖负荷和葡萄糖负荷后，血清半乳糖水平的升高明显低于单用半乳糖负荷，但高于等剂量半乳糖和葡萄糖负荷。从以上所述，当新生儿口服乳糖时，未观察到血清半乳糖浓度增加，这一事实部分归因于葡萄糖在肠中对半乳糖的吸收受到抑制，但大部分归因于吸收的葡萄糖加速了半乳糖的代谢。
1. A lactose tolerance test was performed in infants and children. The majority of the infants showed a good response with serum glucose elevations, while there were poor responders among children more than 2 years old. During this test, serum galactose usually was nondetectable, even in the good responders. 2. After simultaneous loading with a constant amount of galactose and varying amounts of glucose in neonates, the degree of elevation of serum galactose levels decreased with increasing amounts of glucose, and loading with equal amounts of galactose and glucose resulted in no elevation of serum galactose levels. 3. In a 6-year-old galactosemic child, serum galactose levels were markedly and continuously elevated after lactose loading. 4. After galactose loading with simultaneous intravenous glucose loading in neonates, elevation of serum galactose was markedly suppressed, as compared with that after galactose loading alone, while it was higher than that after oral loading with the equal doses of galactose and glucose. From the above, the fact that no increase was observed in serum galactose concentration when lactose was loaded orally in neonates is ascribable partially to inhibited absorption of galactose by glucose in the intestine but in the most part to accelerated metabolism of galactose by the glucose absorbed.