A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene
A study on the polymorphism of human MHC class I-related MR1 gene and identification of an MR1-like pseudogene
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DOI：
10.1034/j.1399-0039.2000.560211.x
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发表时间：
2000-08-01
期刊：
影响因子：
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通讯作者：
Martínez-Naves, E
中科院分区：
文献类型：
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作者：
Parra-Cuadrado, JF;Navarro, P;Martínez-Naves, E
人类MR 1是最近发现的，广泛转录的基因，与HLA I类基因座非常相似，功能未知。小鼠和大鼠的MR1序列也被描述为与人类基因具有高度相似性。这项工作的目的是研究人类MR 1是否具有多态性。我们发现，从不同种族来源的样品中获得的MR1特异性聚合酶链反应（PCR）产物的DNA序列是不变的，除了在一个情况下，其中两个沉默突变被检测到。我们还发现了一个与先前描述的序列有显著差异的MR 1样序列，其中最显著的是α 2结构域中的终止密码子，表明它是假基因。
Human MR1 is a recently discovered, ubiquitously transcribed gene very similar to the HLA class I loci and of unknown function. Mouse and rat MR1 sequences have also been described showing high similarity with the human gene. The goal of this work was to investigate if human MR1 was polymorphic. We have found that DNA sequences of MR1-specific polymerase chain reaction (PCR) products obtained from samples of diverse ethnic origin were invariant except in one case in which two silent mutations were detected. We also found an MR1-like sequence displaying significant differences with the previously described, the most remarkable of which is a STOP codon in the alpha 2 domain indicating that is a pseudogene.