Risk factors for breast cancer: A case-control study of screen-detected breast cancer in Miyagi prefecture, Japan
Risk factors for breast cancer: A case-control study of screen-detected breast cancer in Miyagi prefecture, Japan
复制标题
DOI：
10.1023/a:1005883221114
复制
发表时间：
1997-07-01
影响因子：
3.8
通讯作者：
Hisamichi, S
中科院分区：
文献类型：
--
作者：
Minami, Y;Ohuchi, N;Hisamichi, S
我们根据1987-1991年期间来自日本宫城县的201，363名乳腺癌筛查计划参与者的信息，研究了生殖因素与乳腺癌风险之间的关系。采用病例对照研究方法进行分析。204例乳腺癌病例和810例筛查年龄，年龄和筛查地区匹配的正常对照的数据被提取。在调整潜在混杂因素后，观察到乳腺癌风险随产次增加而降低的趋势（趋势p = 0.03）。在经产妇女中，最后一个孩子哺乳可降低乳腺癌风险（比值比（OR）= 0.61，95%置信区间（95%CI）0.39-0.94）。这些发现与以前报道的临床乳腺癌的结果一致。当病例分为两个年龄组时，年轻（小于或等于49岁）50岁以上（50 y.o.）小于或等于）、母亲和姐妹篇中有乳腺癌家族史（OR = 3.51，95%CI 1.05-11.80）和最后一个孩子哺乳（OR = 0.46，95%CI 0.25-0.84）与年轻乳腺癌相关，而产次数与老年乳腺癌相关（趋势p = 0.03）。按年龄组划分的结果表明，乳腺癌在早期和晚期发病时可能存在不同的机制。
We examined the associations between reproductive factors and the risk of breast cancer on the basis of information from a total of 201,363 breast cancer screening program participants in Miyagi Prefecture, Japan, during 1987-1991. A case-control study method was applied on analysis. Data on 204 breast cancer cases identified and 810 screening year-, age- and screening area-matched normal controls were extracted. After adjustment for potential confounders, a trend of decreasing risk of breast cancer with increasing number of parity was observed (p for trend = 0.03) Among parous women, lactation for the last child decreased the risk of breast cancer (odds ratio (OR) = 0.61, 95 % confidence interval (95 % CI) 0.39-0.94). These findings were consistent with those in clinical breast cancer reported previously. When cases were divided into two age groups, younger (less than or equal to 49 y.o.) and older (50 y.o. less than or equal to), family history of breast cancer among mother and sisters (OR = 3.51, 95% CI 1.05-11.80), and lactation for the last child (OR = 0.46, 95% CI 0.25-0.84) were associated with younger age breast cancer, whereas number of parity was associated with older age breast cancer (p for trend = 0.03). The results by age group suggest that different mechanisms may exist in breast cancer developing at early and late onsets.