Chickenpox and stroke in childhood - A study of frequency and causation
Chickenpox and stroke in childhood - A study of frequency and causation
复制标题
DOI：
10.1161/01.str.32.6.1257
复制
发表时间：
2001-06-01
期刊：
影响因子：
8.3
通讯作者：
deVeber, G
中科院分区：
文献类型：
--
作者：
Askalan, R;Laughlin, S;deVeber, G
背景和目的 - 本研究的目的是确定水痘感染是否是儿童动脉缺血性中风 (AIS) 的原因。 方法 - 首先，在 2 个机构对患有 AIS 的幼儿（6 个月至 10 岁）进行了一项前瞻性队列研究（队列研究）。确定 AIS 前 12 个月内是否存在水痘感染，并与健康儿科人群中公布的水痘感染频率进行比较。比较了水痘和非水痘研究队列中 AIS 的临床和影像学特征。其次，对水痘相关的 AIS 进行了文献检索，并将其临床和影像学特征与非水痘队列研究进行了比较。 结果 - 在队列研究中，70 名连续患有 AIS 的儿童中，有 22 名（31%）在前一年曾感染过水痘，而健康人群中这一比例为 9%。水痘队列中的儿童更有可能发生基底神经节梗塞（P
Background and Purpose - The purpose of this study was to determine whether infection with varicella is causal for arterial ischemic stroke (AIS) in children.Methods - First, a prospective cohort study was conducted in young children (aged 6 months to 10 years) with AIS at 2 institutions (cohort study). The presence of varicella infection < 12 months before AIS was determined and compared with the published frequency of varicella infection in the healthy pediatric population. The clinical and radiographic features of AIS were compared between the varicella and nonvaricella study cohorts. Second, a literature search of varicella-associated AIS was conducted, and the clinical and radiographic features were compared with the study nonvaricella cohort.Results - In the cohort study, 22 (31%) of 70 consecutive children with AIS had a varicella infection in the preceding year compared with 9% in the healthy population. Children in the varicella cohort were more likely to have basal ganglia infarcts (P