Neuropsychological functioning in migraine headache, nonheadache chronic pain, and mild traumatic brain injury patients
Neuropsychological functioning in migraine headache, nonheadache chronic pain, and mild traumatic brain injury patients
复制标题
DOI：
10.1016/s0887-6177(98)00020-1
复制
发表时间：
1999-05-01
影响因子：
2.6
通讯作者：
Lofland, KR
中科院分区：
文献类型：
--
作者：
Bell, BD;Primeau, M;Lofland, KR
关于偏头痛患者的神经心理功能，文献中有相互矛盾的报道。一些研究发现，偏头痛患者的表现比健康对照组更差，这导致了慢性偏头痛可能导致轻微但持续的大脑功能障碍的假设。关于偏头痛患者急性和头痛间期神经生理紊乱的报道支持了这一假说。为了阐明这些患者的认知状态，我们对60例偏头痛（HA）、非头痛性慢性疼痛（pain）或轻度创伤性脑损伤（MTBI）患者进行了简短的神经心理学测试。纳入PAIN组是为了验证偏头痛患者的认知困难可能是由通常与慢性疼痛相关的不适、抑郁、药物等引起的假设，而不是由大脑功能障碍引起的。MTBI患者被认为是偏头痛患者的一个有用的比较，因为他们的损伤水平也被认为是轻微的，在最坏的情况下，以三个认知指数得分作为因变量的方差分析显示，三组患者差异显著。随访对比表明，与HA和PAIN组相比，MTBI组在记忆指数上的损害明显更大，但两者之间没有差异。使用两种不同的基于规范的截止值来识别在测试电池中受损的个体，结果显示两组疼痛患者（而非MTBI患者）的损伤频率在正常范围内。因此，结果不支持偏头痛和认知障碍之间的联系(C) 1999年国家神经心理学学会。Elsevier Science Ltd.出版。
There are conflicting reports in the literature concerning the neuropsychological functioning of migraine headache patients. The finding in some studies that migraineurs performed more poorly than healthy controls led to the hypothesis that chronic migraine may result in subtle but persistent cerebral dysfunction. Reports describing acute and between-headache neurophysiological disturbances in migraineurs lent support to this hypothesis. To elucidate the cognitive status of these patients, we administered a brief neuropsychological battery to 60 individuals with migraine headache (HA), nonheadache chronic pain (PAIN), or mild traumatic brain injury (MTBI). The PAIN group was included to test the hypothesis that cognitive difficulty in migraineurs might result from the discomfort, depression, medications, etc. often associated with chronic pain, rather than from brain dysfunction. The MTBI patients were considered a useful comparison for the migraineurs because their level of impairment was also expected to be mild, at worst A MANOVA, with three cognitive index scores as the dependent variables, revealed that the three groups differed significantly. Follow-up contrasts demonstrated that the MTBI group was significantly more impaired on the memory index compared to the HA and PAIN groups, which did not differ from each other. The use of two different normative-based cutoffs to identify individuals who were impaired on the test battery revealed that the frequency of impairment within the two groups of pain patients, but not the MTBI patients, was within normal limits. Thus, the results did not support a link between migraine headache and cognitive impairment (C) 1999 National Academy of Neuropsychology. Published by Elsevier Science Ltd.