Pathology identifies glomerular treatment targets in diabetic nephropathy.
Pathology identifies glomerular treatment targets in diabetic nephropathy.
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DOI：
10.23876/j.krcp.2018.37.2.106
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发表时间：
2018-06
影响因子：
3
通讯作者：
Hudkins KL
中科院分区：
文献类型：
--
作者：
Alpers CE;Hudkins KL
糖尿病肾病肾小球损伤的发生涉及足细胞、内皮和系膜之间的相互作用。足细胞的丧失是糖尿病肾病发展的早期且关键的一步，对系膜内结构病变（例如系膜溶解）的分析表明足细胞的丧失是一个关键的介导事件。 BTBR ob/ob 小鼠已被证明是一个有用的工具，它证明了足细胞密度的恢复（一度被认为是肾小球修复的绝对障碍）可以通过替换这些小鼠中基本不存在的瘦素激素来实现。在该模型中，足细胞密度的恢复与形态学晚期糖尿病肾小球损伤的结构损伤的逆转相关。这一发现与在患有形态学晚期糖尿病肾病和长期功能性胰腺移植十年的人类糖尿病患者中的证明相结合，表明他们的糖尿病肾病可以逆转，表明恢复足细胞数量和密度是开发糖尿病肾病新疗法的适当目标。
The development of the glomerular injury in diabetic nephropathy involves interactions between podocytes, endothelium, and the mesangium. Loss of podocytes is an early and critical step in the development of diabetic nephropathy, and analysis of structural lesions within the mesangium such as mesangiolysis implicate the loss of podocytes as a key mediating event. The BTBR ob/ob mouse has proved a useful tool to demonstrate that restoration of podocyte density, once thought to be an absolute barrier to glomerular repair, can be achieved with replacement of the hormone leptin that is constitutively absent in these mice. Restoration of podocyte density is associated with reversal of the structural lesions of morphologically advanced diabetic glomerular injury in this model. This finding, in conjunction with the demonstration in human diabetic patients with morphologically advanced diabetic nephropathy and with long-standing functioning pancreatic transplants of ten years duration that their diabetic nephropathy can be reversed, suggests that restoration of podocyte number and density is an appropriate target for the development of new therapeutics for diabetic nephropathy.
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影响因子：
13.6
作者：
Pichaiwong, Warangkana;Hudkins, Kelly L.;Alpers, Charles E.
通讯作者：
Alpers, Charles E.
影响因子：
19.6
作者：
Andeen NK;Nguyen TQ;Steegh F;Hudkins KL;Najafian B;Alpers CE
通讯作者：
Alpers CE
影响因子：
6
作者：
Pippin, Jeffrey W.;Sparks, Matthew A.;Shankland, Stuart J.
通讯作者：
Shankland, Stuart J.
影响因子：
158.5
作者：
Eremina, Vera;Jefferson, J. Ashley;Quaggin, Susan E.
通讯作者：
Quaggin, Susan E.
影响因子：
158.5
作者：
Fioretto, P;Steffes, MW;Mauer, M
通讯作者：
Mauer, M