Brain mechanisms involved in predatory aggression are activated in a laboratory model of violent intra‐specific aggression
Brain mechanisms involved in predatory aggression are activated in a laboratory model of violent intra‐specific aggression
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涉及掠夺性攻击的大脑机制在暴力特定内攻击的实验室模型中被激活
DOI：
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发表时间：
2010
影响因子：
3.4
通讯作者：
J. Haller
中科院分区：
文献类型：
--
作者：
Á. Tulogdi;M. Tóth;J. Halasz;É. Mikics;Tamas Fuzesi;J. Haller
与反社会人格障碍相关的冷酷无情的暴力行为通常被称为“掠夺性”，因为它涉及限制的意图信号和低情绪/生理唤醒，包括糖皮质激素的产生减少。这个绰号可能只是一个隐喻，但也可能涵盖了下丘脑水平的结构相似性，在下丘脑水平上，情感和掠夺性攻击的控制是不同的。我们在一个实验室模型中研究了这一假设，在该模型中，糖皮质激素的产生长期受到肾上腺切除术和糖皮质激素替代（ADXr）的限制。这一程序被提出来模拟反社会暴力的重要方面。将假手术和ADXr大鼠提交给居民/入侵者冲突，并通过c-Fos免疫细胞化学研究所得的神经元激活模式。与早期的研究结果一致，针对易受攻击目标（头部、喉咙和腹部）的攻击比例在ADXr中大幅增加，而攻击性威胁发出的意图信号则受到限制。攻击性遭遇激活了下丘脑内侧基底核，这是一个参与种内攻击的区域，但假手术和ADXr大鼠在这方面没有差异。相比之下，ADXr大鼠中与掠夺性攻击密切相关的外侧下丘脑的激活明显更大;此外，c-Fos计数与脆弱攻击的比例呈正相关，与社会信号呈负相关。糖皮质激素缺乏增加了中央杏仁核中的c-Fos激活，该区域也参与了掠夺性攻击。此外，中脑导水管周围灰质的激活模式--涉及自主控制--也类似于在掠夺性攻击中所看到的。这些发现表明，反社会和掠夺性攻击不仅相似，而且由重叠的神经机制控制。
Callous‐unemotional violence associated with antisocial personality disorder is often called ‘predatory’ because it involves restricted intention signaling and low emotional/physiological arousal, including decreased glucocorticoid production. This epithet may be a mere metaphor, but may also cover a structural similarity at the level of the hypothalamus where the control of affective and predatory aggression diverges. We investigated this hypothesis in a laboratory model where glucocorticoid production is chronically limited by adrenalectomy with glucocorticoid replacement (ADXr). This procedure was proposed to model important aspects of antisocial violence. Sham and ADXr rats were submitted to resident/intruder conflicts, and the resulting neuronal activation patterns were investigated by c‐Fos immunocytochemistry. In line with earlier findings, the share of attacks aimed at vulnerable targets (head, throat and belly) was dramatically increased by ADXr, while intention signaling by offensive threats was restricted. Aggressive encounters activated the mediobasal hypothalamus, a region involved in intra‐specific aggression, but sham and ADXr rats did not differ in this respect. In contrast, the activation of the lateral hypothalamus that is tightly involved in predatory aggression was markedly larger in ADXr rats; moreover, c‐Fos counts correlated positively with the share of vulnerable attacks and negatively with social signaling. Glucocorticoid deficiency increased c‐Fos activation in the central amygdala, a region also involved in predatory aggression. In addition, activation patterns in the periaqueductal gray – involved in autonomic control – also resembled those seen in predatory aggression. These findings suggest that antisocial and predatory aggression are not only similar but are controlled by overlapping neural mechanisms.