The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence
The Role of Stress Granules and the Nonsense-mediated mRNA Decay Pathway in Antiviral Defence
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DOI：
10.2533/chimia.2019.374
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发表时间：
2019-05-01
期刊：
影响因子：
1.2
通讯作者：
Muhlemann, Oliver
中科院分区：
文献类型：
--
作者：
Contu, Lara;Steiner, Silvio;Muhlemann, Oliver
真核细胞已经进化出许多生存策略和质量控制途径，能够对抗内在的易错机制，并允许在面对外部压力时维持细胞内稳态。这篇综述将讨论两个细胞真核过程的作用，这是至关重要的维持细胞内环境的稳定-1）无义介导的mRNA衰变（NMD）途径和2）的瞬时形成的应激颗粒（SG）-并探讨其在抗病毒防御的作用，目前的文献。在NCCR RNA和疾病，实验室的Proffs。O. Muhlemann和Volker Thiel合作解开了NMD和SGs的作用，以及它们在保护细胞免受甲病毒和冠状病毒感染方面的相互联系。
Eukaryotic cells have evolved a number of survival tactics and quality control pathways that are able to counter intrinsic error-prone mechanisms and allow for maintenance of cellular homeostasis in the face of external stresses. This review will discuss the role of two cellular eukaryotic processes that are vital for maintenance of cellular homeostasis -1) the nonsense-mediated mRNA decay (NMD) pathway and 2) the transient formation of stress granules (SG) - and explore the current literature on their roles in antiviral defence. Within the NCCR RNA & Disease, the laboratories of Proffs. O. Muhlemann and Volker Thiel teamed up to unravel the roles of NMD and SGs, and their interconnections in defending cells from alphavirus and coronavirus infections.