Intrarenal corpuscular multinucleated giant cells in ANCA-associated vasculitis.
Intrarenal corpuscular multinucleated giant cells in ANCA-associated vasculitis.
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ANCA 相关血管炎中的肾内红细胞多核巨细胞。
DOI：
10.1007/s10157-022-02279-w
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Iwano M.
中科院分区：
文献类型：
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作者：
Shimamoto Y;Kasuno K;Iwano M.
一名65岁的男性，无特殊病史。实验室数据显示肾功能迅速恶化，血清肌酐为2.6 mg/dL。抗中性粒细胞胞浆抗体（ANCA）升高（MPOANCA 152.5 U/mL和PR 3-ANCA 43.8 U/mL）。临床、血清学和组织病理学结果符合肉芽肿伴多血管炎的诊断标准（图1）。有趣的是，在两个肾小球新月体中检测到位于细胞质外周区域的含有4至7个核的MGCs，其对CD 68呈阳性（图1A和1B）。第2、3段）。
A 65-year-old man with no specific medical history was admitted. Laboratory data revealed rapidly worsening renal function of serum creatinine of 2.6 mg/dL. Anti-neutrophil cytoplasmic antibodies (ANCAs) were elevated (MPOANCA 152.5 U/mL and PR3-ANCA 43.8 U/mL). Clinical, serological, and histopathological findings met the diagnostic criteria for granulomatosis with polyangiitis (Fig. 1). Interestingly, MGCs containing 4 to 7 nuclei situated in peripheral areas of the cytoplasm were detected in two glomerular crescents, which were positive for CD68 (Figs. 2, 3).