ANTINOCICEPTIVE EFFECT OF SPINALLY DELIVERED PROSTAGLANDIN-E RECEPTOR ANTAGONISTS IN THE FORMALIN TEST ON THE RAT
ANTINOCICEPTIVE EFFECT OF SPINALLY DELIVERED PROSTAGLANDIN-E RECEPTOR ANTAGONISTS IN THE FORMALIN TEST ON THE RAT
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DOI：
10.1016/0304-3940(94)90181-3
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发表时间：
1994-05-23
影响因子：
2.5
通讯作者：
YAKSH, TL
中科院分区：
文献类型：
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作者：
MALMBERG, AB;RAFFERTY, MF;YAKSH, TL
使用福尔马林试验在大鼠中检查了脊髓给药的前列腺素E（2）受体拮抗剂SC-51089和SC-51234 A（对EP 1受体具有选择性）的抗伤害感受作用。鞘内注射SC-51089（30-300 μ g）或SC-51234 A（30-300 μ g）导致对福尔马林注射到爪中诱发的退缩行为的第二阶段（10-60 min）的显著、剂量依赖性抑制，但对第一阶段（0-9 min）无抑制。SC-51089和SC-51234 A第二阶段的艾德（25）值和95%置信区间分别为120（70-200）μ g和80（50-140）μ g。这些数据表明，脊髓前列腺素E（2）受体拮抗剂可减弱特定的伤害性行为，并提示前列腺素E（2）参与脊髓水平的易化加工。
The antinociceptive effect of spinally administered prostaglandin E(2) receptor antagonists, SC-51089 and SC-51234A, which are selective for EP1 receptors, was examined in rats using the formalin test. Intrathecal injection of SC-51089 (30-300 mu g) or SC-51234A (30-300 mu g) resulted in a significant, dose-dependent, suppression of the second phase (10-60 min), but not the first phase (0-9 min), flinching behavior evoked by formalin injection into the paw. ED(25) values and 95% confidence intervals for the second phase were 120 (70-200) mu g for SC-51089 and 80 (50-140) mu g for SC-51234A. These data demonstrate that specific nociceptive behaviors are attenuated by spinal prostaglandin E(2) receptor antagonists and suggest that prostaglandin E(2) is involved in facilitated processing at the spinal level.