Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection
Metalloproteinases and Brain Arterial Remodeling Among Individuals With and Those Without HIV Infection
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DOI：
10.1093/infdis/jiw385
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发表时间：
2016-11-01
影响因子：
6.4
通讯作者：
Morgello, Susan
中科院分区：
文献类型：
--
作者：
Gutierrez, Jose;Menshawy, Khaled;Morgello, Susan
背景。方法：对84例HIV阳性脑组织和78例HIV阴性脑组织的欧洲整体大动脉进行金属蛋白酶2 （MMP-2）、MMP-3、MMP-9、金属蛋白酶组织抑制剂1 （TIMP-1）、TIMP-2、CD68和caspase 3的染色。自动获得平均像素强度，并将其分类为高、中、低。结果：仅在hiv阴性个体中，单独高MMP-9染色（P = 0.001）或与低TIMP-2染色共存的欧洲积分高MMP-9染色与dolicho扩张相关（P = 0.001）
Background. This study tests the hypothesis that increased elastolytic activity is associated differentially with dolichoectasia in individuals with and those without human immunodeficiency virus (HIV) infection.Methods.aEuro integral Large arteries from 84 autopsied brains from HIV-positive individuals and 78 autopsied brains from HIV-negative individuals were stained for metalloproteinase 2 (MMP-2), MMP-3, MMP-9, tissue inhibitor of metalloproteinases 1 (TIMP-1), TIMP-2, CD68, and caspase 3. Average pixel intensity was automatically obtained and categorized as high, moderate, or low. Dolichoectasia was defined as a lumen to wall ratio a parts per thousand yen95th percentile.Results.aEuro integral High MMP-9 staining alone (P = .001) or coexistent with low TIMP-2 staining was associated with dolichoectasia only in HIV-negative individuals (P =