Global dynamics of a cholera model with age structures and multiple transmission modes

Global dynamics of a cholera model with age structures and multiple transmission modes
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具有年龄结构和多种传播模式的霍乱模型的全球动态

DOI:
10.1142/s1793524519500517
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发表时间:
2019-08
影响因子:
2.2
通讯作者:
Chen Yuming
Chen Yuming
中科院分区:
数学2区
文献类型:
--
作者:
Wang Xia;Chen Yuming

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在本文中,我们提出并分析了霍乱模型。该模型结合了直接传播(人与人之间的传播)和间接传播(污染环境与人之间的传播:高传染性和低传染性)。此外,我们采用一般非线性发生率并引入感染个体的感染年龄和环境中病原体的生物学年龄。在考虑系统的适定性后,我们研究了由基本再生数决定的稳态的存在性和局部稳定性。为了建立感染稳态的吸引力,我们还得到了紧凑全局吸引子的一致持久性和存在性。主要结果是通过应用涨落引理和李亚普诺夫泛函方法获得的阈值动力学。当基本再生数小于1时,无感染稳态是全局渐近稳定的;而当基本再生数大于1时,感染稳态在某个时间点以非零感染力吸引各个解。还讨论了多种传播模式对疾病动态的影响。
In this paper, we propose and analyze a cholera model. The model incorporates both direct transmission (person-to-person transmission) and indirect transmission (contaminated environment-to-person transmission: hyper-infectivity and lower-infectivity). Moreover, we employ general nonlinear incidences and introduce infection age of infectious individuals and biological ages of pathogens in the environment. After considering the well-posedness of the system, we study the existence and local stability of steady states, which is determined by the basic reproduction number. To establish the attractivity of the infection steady state, we also get the uniform persistence and existence of compact global attractors. The main result is a threshold dynamics obtained by applying the Fluctuation Lemma and the approach of Lyapunov functionals. When the basic reproduction number is less than one, the infection-free steady state is globally asymptotically stable while when the basic reproduction number is larger than one, the infection steady state attracts each solution with nonzero infection force at some time point. The effect of multiple transmission modes on the disease dynamics is also discussed.
具有非线性发病率和清除率的一般霍乱模型的全局稳定性
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