Chronic Limb Remote Ischemic Conditioning may have an Antihypertensive Effect in Patients with Hypertension.
Chronic Limb Remote Ischemic Conditioning may have an Antihypertensive Effect in Patients with Hypertension.
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DOI：
10.14336/ad.2021.0604
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发表时间：
2021-12
影响因子：
7.4
通讯作者：
Ji X
中科院分区：
文献类型：
--
作者：
Guo W;Ren C;Zhang B;Zhao W;Gao Y;Yu W;Ji X
高血压是全球全因发病率和死亡率的主要可预防危险因素。尽管抗高血压药物已经问世数十年，但我们面临的一大挑战是提高人群的血压（BP）控制率。因此，有必要寻找新的降压手段，减轻高血压带来的疾病负担。肢体远程缺血调节（LRIC）可以通过肢体短暂和反复的缺血触发内源性保护作用，以保护包括脑、心脏和肾脏在内的特定器官和组织。 LRIC的机制涉及调节自主神经系统、释放体液因子、改善血管内皮功能以及调节免疫/炎症反应。 LRIC的这些潜在机制理论上可能通过多种途径抑制高血压的发病机制，从而导致血压潜在下降。现有的几项研究探讨了 LRIC 对血压的影响，但报告的结果存在争议。为了探讨 LRIC 的潜在抗高血压作用及其潜在机制，我们系统地回顾了相关文章，以深入了解高血压的新疗法。
Hypertension is the leading preventable risk factor for all-cause morbidity and mortality worldwide. Despite antihypertensive medications have been available for decades, a big challenge we are facing is to increase the blood pressure (BP) control rate among the population. Therefore, it is necessary to search for new antihypertensive means to reduce the burden of disease caused by hypertension. Limb remote ischemic conditioning (LRIC) can trigger endogenous protective effects through transient and repeated ischemia on the limb to protect specific organs and tissues including the brain, heart, and kidney. The mechanisms of LRIC involve the regulation of the autonomic nervous system, releasing humoral factors, improvement of vascular endothelial function, and modulation of immune/inflammatory responses. These underlying mechanisms of LRIC may restrain the pathogenesis of hypertension through multiple pathways theoretically, leading to a potential decline in BP. Several existing studies have explored the impact of LRIC on BP, however, controversial findings were reported. To explore the potential antihypertensive effect of LRIC and the underlying mechanisms, we systematically reviewed the relevant articles to provide an insight into the novel therapy of hypertension.