Prognostic factors and outcomes of patients with myxofibrosarcoma.
Prognostic factors and outcomes of patients with myxofibrosarcoma.
复制标题
DOI：
10.1245/s10434-012-2572-3
复制
发表时间：
2013-01
影响因子：
3.7
通讯作者：
Mullen JT
中科院分区：
文献类型：
--
作者：
Look Hong NJ;Hornicek FJ;Raskin KA;Yoon SS;Szymonifka J;Yeap B;Chen YL;DeLaney TF;Nielsen GP;Mullen JT
粘液纤维肉瘤（MFS）是一组具有局部复发倾向的异质性肿瘤。本研究的目的是分析在单一机构接受治疗的MFS患者的预后因素和结局。我们回顾性分析了从1995年8月至2010年11月接受手术治疗的69例经病理证实的四肢或浅表躯干MFS患者的记录。回顾了临床病理特征、治疗和患者结局。确定了69例患者，其中38例为男性（55%）。中位年龄为62岁。64名患者（93%）表现为原发性肿瘤，5名患者（7%）表现为局部复发性肿瘤。中位肿瘤大小为6.0 cm，44例患者（64%）为3级肿瘤（FNCLCC [Fédération Nationale des Centres de Lutte Contre le Cancer]分类）。14例患者（20%）显微镜下切缘阳性，55例患者（80%）为阴性，包括14例患者（20%）的闭合切缘（<1 mm）。53例患者（77%）接受了放疗。在中位随访41个月时，有11例局部（16%）和11例远端（16%）复发。局部和远处5年无复发生存率分别为72%和82%，5年总生存率为61%。年龄增加（按0.1比例缩放;风险比[HR] 1.80，P = 0.002）和肿瘤大小（HR 1.12，P = 0.004）与总生存率呈负相关。切缘阳性/闭合（<1 mm）状态（HR 4.34，P = 0.030）预测局部无复发生存率恶化。MFS表现出局部复发的倾向，这是通过切除阳性或接近边缘来预测的。积极的手术结合放射治疗可能有助于更有效的局部控制。
Myxofibrosarcomas (MFS) are a historically heterogeneous group of tumors that exhibit a propensity for local recurrence. The objectives of this study were to analyze the prognostic factors and outcomes of patients with MFS treated at a single institution. We retrospectively reviewed the records of 69 consecutive patients with pathologically confirmed MFS of the extremities or superficial trunk who underwent surgery from August 1995 to November 2010. Clinicopathologic features, treatments, and patient outcomes were reviewed. Sixty-nine patients were identified, of whom 38 were men (55 %). The median age was 62 years. Sixty-four patients (93 %) presented with primary tumors, and 5 patients (7 %) presented with locally recurrent tumors. Median tumor size was 6.0 cm, and 44 patients (64 %) had grade 3 tumors (FNCLCC [Fédération Nationale des Centres de Lutte Contre le Cancer] classification). Margins were microscopically positive in 14 patients (20 %) and negative in 55 patients (80 %), including close margins (<1 mm) in 14 patients (20 %). Fifty-three patients (77 %) received radiotherapy. At a median follow-up of 41 months, there were 11 local (16 %) and 11 distant (16 %) recurrences. The local and distant 5-year recurrence-free survival rates were 72 % and 82 %, and the 5-year overall survival was 61 %. Increased age (scaled by 0.1; hazard ratio [HR] 1.80, P = 0.002) and tumor size (HR 1.12, P = 0.004) were negatively correlated with overall survival. Positive/close (<1 mm) margin status (HR 4.34, P = 0.030) predicted worsened local recurrence-free survival. MFS exhibit a propensity for local recurrence, which is predicted by resection with positive or close margins. Aggressive surgery combined with radiotherapy may contribute to more effective local control.
登录
查看更多内容
影响因子：
45.3
作者：
Pisters, PWT;Harrison, LB;Brennan, MF
通讯作者：
Brennan, MF
影响因子：
45.3
作者：
Fletcher, CDM;Gustafson, P;Åkerman, M
通讯作者：
Åkerman, M
影响因子：
2.1
作者：
Kaya, Mitsunori;Wada, Takuro;Yamashita, Toshihiko
通讯作者：
Yamashita, Toshihiko
DOI：
10.1097/01.blo.0000229292.98850.14
发表时间：
2006-09-01
影响因子：
4.2
作者：
Manoso, Mark W.;Pratt, Jeffrey;Athanasian, Edward A.
通讯作者：
Athanasian, Edward A.
影响因子：
5
作者：
Waters, Brendan;Panicek, David M.;Brennan, Murray F.
通讯作者：
Brennan, Murray F.