Long-term contextual memory in infant rats as evidenced by an ethanol conditioned tolerance procedure.
Long-term contextual memory in infant rats as evidenced by an ethanol conditioned tolerance procedure.
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乙醇条件耐受程序证明了幼鼠的长期情境记忆。
DOI：
10.1016/j.bbr.2017.06.007
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发表时间：
2017
影响因子：
2.7
通讯作者：
Arias,Carlos
中科院分区：
文献类型：
--
作者：
Castelló,Stefanía;Molina,JuanCarlos;Arias,Carlos
条件性耐受可以被概念化为巴甫洛夫条件反射的一个特殊情况，在这种情况下，情境线索起着条件刺激的作用。虽然证据是矛盾的，它经常被认为是长期的背景条件在断奶前的大鼠是弱的，甚至没有。这一假说主要来自行为研究，这些研究使用恐惧条件反射范式探索了16-18日龄大鼠的不同情境效应，但他们的结论是根据不成熟的（依赖于记忆的）陈述性记忆系统来陈述的。本手稿的主要目标是基于我们实验室最近的先例，以分析在断奶前阶段由乙醇诱导的上下文依赖性耐受性是否随时间持续。结果表明，上下文能够调节乙醇诱导的耐受性在2-和3周龄的大鼠。有趣的是，上下文条件耐受性更强（持久性方面）在第三比在第二出生后一周。当受试者在训练8天后接受测试时，当环境可能失去对耐受性的影响时，出现了相反的效果（敏感化）。这些结果是重要的乙醇文献，增加了新的证据，长期保留乙醇的影响，在婴儿期获得，同时也显示出显着的个体发育差异的敏感性，乙醇之间的第2和第3出生后几周。重要的是，上下文信息调制这些乙醇的影响，即使在训练后8天的表达，结果是特别相关的上下文记忆的个体发生的讨论。
Conditioned tolerance can be conceptualized as a particular case of Pavlovian conditioning in which contextual cues play the role of the conditioned stimulus. Although the evidence is contradictory, it is frequently assumed that long-term contextual conditioning in pre-weanling rats is weak or even absent. This hypothesis comes from and is sustained mainly by behavioral studies that explored different contextual effects in 16–18 day-old rats using a fear-conditioning paradigm, but their conclusions are stated in terms of an immature (hippocampal-dependent) declarative memory system. The main goal of the present manuscript was based on a recent antecedent from our laboratory, to analyze whether context-dependent tolerance induced by ethanol during the pre-weanling period persists over time. Results showed that the context was able to modulate ethanol-induced tolerance in 2- and 3-week-old rats. Interestingly, contextual conditioned tolerance was stronger (in terms of persistence) during the third than during the second postnatal week. When subjects were tested 8 days after training, when the context presumably lost its influence over tolerance, the opposite effect emerged (sensitization). These results are important for the ethanol literature, adding new evidence of long-term retention of ethanol effects acquired during infancy, whilst also showing striking ontogenetic differences in the sensitivity to ethanol between the 2nd and 3rd postnatal weeks. Importantly, contextual information modulates the expression of these ethanol effects even eight days after training, a result that is particularly relevant to the discussion of the ontogeny of contextual memory.