Maternal Feeding Controls Fetal Biological Clock
Maternal Feeding Controls Fetal Biological Clock
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DOI：
10.1371/journal.pone.0002601
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发表时间：
2008-07-02
期刊：
影响因子：
3.7
通讯作者：
Okamura, Kunihiro
中科院分区：
文献类型：
--
作者：
Ohta, Hidenobu;Xu, Shanhai;Okamura, Kunihiro
背景资料：人们普遍认为，胎儿的昼夜生理节律受到母体大脑中与环境光暗（LD）周期耦合的振荡器的影响。方法学/主要发现：为了研究胎儿和母亲生物钟之间的联系，我们研究了母体食物周期对胎儿视交叉上核（SCN）Per 1基因表达节律的影响。和肝脏，使用其组织在体外表达荧光素酶的转基因大鼠模型。虽然母亲SCN保持锁相的LD周期，母亲限制喂养阶段提前胎儿SCN和肝脏分别由5和7小时内的22天pregnancy.Conclusions/Significance：我们的研究结果表明，母亲喂养夹带胎儿SCN和肝脏独立的母亲SCN和LD周期。这表明母体喂养信号对胎儿SCN和特定器官振荡器的影响可能比母体SCN控制的激素信号更大，这表明在怀孕期间定期母体喂养时间表对适当的胎儿分子钟表的重要性。
Background: It is widely accepted that circadian physiological rhythms of the fetus are affected by oscillators in the maternal brain that are coupled to the environmental light-dark (LD) cycle.Methodology/Principal Findings: To study the link between fetal and maternal biological clocks, we investigated the effects of cycles of maternal food availability on the rhythms of Per1 gene expression in the fetal suprachiasmatic nucleus (SCN) and liver using a transgenic rat model whose tissues express luciferase in vitro. Although the maternal SCN remained phase-locked to the LD cycle, maternal restricted feeding phase-advanced the fetal SCN and liver by 5 and 7 hours respectively within the 22-day pregnancy.Conclusions/Significance: Our results demonstrate that maternal feeding entrains the fetal SCN and liver independently of both the maternal SCN and the LD cycle. This indicates that maternal-feeding signals can be more influential for the fetal SCN and particular organ oscillators than hormonal signals controlled by the maternal SCN, suggesting the importance of a regular maternal feeding schedule for appropriate fetal molecular clockwork during pregnancy.