3D printing of versatile reactionware for chemical synthesis
3D printing of versatile reactionware for chemical synthesis
复制标题
DOI：
10.1038/nprot.2016.041
复制
发表时间：
2016-05-01
期刊：
影响因子：
14.8
通讯作者：
Cronin, Leroy
中科院分区：
文献类型：
--
作者：
Kitson, Philip J.;Glatzel, Stefan;Cronin, Leroy
近几十年来，3D打印（也称为增材制造）技术已经超越了其在工业制造和原型领域的传统应用，越来越多地在合成化学等科学研究领域发挥作用。我们提出了一种生产定制化学反应器的通用方法，称为反应器，使用两种不同的基于挤出的3D打印方法。该方案描述了使用两种不同的3D打印机设置打印惰性聚丙烯（PPPP）结构，同时打印软材料催化剂复合材料。程序的步骤描述了所需反应器皿装置的3D数字模型的设计和制备，以及该模型的制备以用于熔融沉积成型（FDM）型3D打印机。然后，该方案进一步描述了用于并入3D打印设备的复合催化剂-硅酮材料的制备以及制造反应器皿设备所需的步骤。这种组合的方法允许在设计和使用的反应器的实验用户的特定需求的基础上的多功能性。为了说明这一点，我们提出了一个详细的程序，用于生产一个这样的反应器皿设备，这将导致生产的密封反应器能够实现多步有机合成。根据3D模型的设计时间，包括材料的固化和干燥时间，该过程可以类似于3D完成。
In recent decades, 3D printing (also known as additive manufacturing) techniques have moved beyond their traditional applications in the fields of industrial manufacturing and prototyping to increasingly find roles in scientific research contexts, such as synthetic chemistry. We present a general approach for the production of bespoke chemical reactors, termed reactionware, using two different approaches to extrusion-based 3D printing. This protocol describes the printing of an inert polypropylene (PPPP) architecture with the concurrent printing of soft material catalyst composites, using two different 3D printer setups. The steps of the PROCEDURE describe the design and preparation of a 3D digital model of the desired reactionware device and the preparation of this model for use with fused deposition modeling (FDM) type 3D printers. The protocol then further describes the preparation of composite catalyst-silicone materials for incorporation into the 3D-printed device and the steps required to fabricate a reactionware device. This combined approach allows versatility in the design and use of reactionware based on the specific needs of the experimental user. To illustrate this, we present a detailed procedure for the production of one such reactionware device that will result in the production of a sealed reactor capable of effecting a multistep organic synthesis. Depending on the design time of the 3D model, and including time for curing and drying of materials, this procedure can be completed in similar to 3 d.