Lapachol and its congeners as anticancer agents: a review
Lapachol and its congeners as anticancer agents: a review
复制标题
DOI：
10.1007/s11101-013-9289-1
复制
发表时间：
2014-03-01
影响因子：
7.7
通讯作者：
Kiss, Robert
中科院分区：
文献类型：
--
作者：
Epifano, Francesco;Genovese, Salvatore;Kiss, Robert
拉帕酚是一种天然存在的1，4-萘醌，最初由意大利植物化学家E。Paterno于1882年从Tabebuia avellanedae（紫葳科）发现，随后在豆科、锦葵科、白花丹科、唇形科、槟榔科、玄参科、马鞭草科、卫矛科、Avicenniaceae、云实科、茜草科和Proteaceae的几个其他属中发现。在文献中已经观察到拉帕胆碱及其半合成衍生物具有广泛的药理活性，例如抗利什曼病、抗癌、抗炎、抗疟疾、防腐、抗肿瘤、抗病毒、杀菌、杀真菌、驱虫、杀虫、杀寄生虫、杀白蚁和杀病毒作用。本综述的目的是详细讨论迄今为止已报道的标题化合物的植物化学性质和药理作用，突出其未来的潜在治疗益处。
Lapachol is a naturally occurring 1,4-naphthoquinone originally isolated by the Italian phytochemist E. Paterno from Tabebuia avellanedae (Bignoniaceae) in 1882 and subsequently found in several other genera belonging to the families of Leguminosae, Malvaceae, Plumbaginaceae, Lamiaceae, Arecaceae, Scrophulariaceae, Verbenaceae, Celastraceae, Avicenniaceae, Caesalpiniaceae, Rubiaceae, and Proteaceae. A wide range of pharmacological activities have been observed for lapachol and its semi-synthetic derivatives in the literature, such as antileishmanial, anticarcinomic, anti-inflammatory, antimalarial, antiseptic, antitumor, antiviral, bactericidal, fungicidal, insectifugal, pesticidal, schistosomicidal, termiticidal, and viricidal effects. The aim of this review is to discuss in detail the phytochemical properties and pharmacological effects of the title compound that have been reported thus far, highlighting its potential therapeutic benefits for the future.