Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
Activation of the Raf-MEK-ERK pathway is required for neutrophil extracellular trap formation
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DOI：
10.1038/nchembio.496
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发表时间：
2011-02-01
影响因子：
14.8
通讯作者：
Waldmann, Herbert
中科院分区：
文献类型：
--
作者：
Hakkim, Abdul;Fuchs, Tobias A.;Waldmann, Herbert
导致中性粒细胞胞外陷阱（NETs）形成的信号机制，与感染、败血症和自身免疫性疾病有关，目前尚不清楚。中性粒细胞不适合用传统的遗传技术进行研究。利用新的化学遗传分析，我们发现Raf-MEK-ERK通路通过激活NADPH氧化酶和上调抗凋亡蛋白参与NET的形成。我们确定了治疗net相关疾病的药物的潜在靶点。
The signaling mechanisms leading to the formation of neutrophil extracellular traps (NETs), relevant in infections, sepsis and autoimmune diseases, are poorly understood. Neutrophils are not amenable to studies with conventional genetic techniques. Using a new chemical genetic analysis we show that the Raf-MEK-ERK pathway is involved in NET formation through activation of NADPH oxidase and upregulation of antiapoptotic proteins. We identify potential targets for drugs addressing NET-associated diseases.