Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer
Randomized controlled trial of mindfulness-based stress reduction (MBSR) for survivors of breast cancer
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DOI：
10.1002/pon.1529
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发表时间：
2009-12-01
期刊：
影响因子：
3.6
通讯作者：
Kip, Kevin E.
中科院分区：
文献类型：
--
作者：
Lengacher, Cecile A.;Johnson-Mallard, Versie;Kip, Kevin E.
目的：乳腺癌（BC）幸存者中持续存在相当高的发病率，包括高水平的心理压力、焦虑、抑郁、对复发的恐惧，以及包括疼痛、疲劳和睡眠障碍在内的身体症状，以及生活质量受损。有效的干预措施是必要的，在这个困难的过渡时期。方法：我们进行了一项随机对照试验的84名女性BC幸存者（阶段0-III）招募从H。李莫菲特癌症研究所。所有受试者均在18个月内完成手术和辅助放疗和/或化疗治疗。受试者被随机分配到一个为期6周的正念减压（MBSR）计划，旨在自我调节对压力环境或症状的唤醒（n = 41）或常规护理（n = 43）。6周时通过随机分配比较的结果指标包括心理状态的有效指标（抑郁、焦虑、压力感受、害怕复发、乐观、社会支持）和生活质量的心理和生理分量表（SF-36）。与常规治疗相比，被分配到MBSR（BC）的受试者（双侧p < 0.05）调整后的平均抑郁水平（6.3 vs 9.6），焦虑（28.3 vs 33.0），以及对复发的恐惧（9.3 vs 11.6），沿着较高的能量（53.5 vs 49.2）、身体功能（50.1 vs 47.0）和身体角色功能（49.1 vs 42.8）。在分层分析中，受试者更符合MBSR往往经历更大的改善措施的能源和身体functioning.Conclusions：BC的幸存者在18个月内完成治疗，6周MBSR（BC）计划导致显着改善心理状态和生活质量相比，通常的护理。版权所有（C）2009约翰威利父子有限公司
Objectives: Considerable morbidity persists among survivors of breast cancer (BC) including high levels of psychological stress, anxiety, depression, fear of recurrence, and physical symptoms including pain, fatigue, and sleep disturbances, and impaired quality of life. Effective interventions are needed during this difficult transitional period.Methods: We conducted a randomized controlled trial of 84 female BC survivors (Stages 0-III) recruited from the H. Lee Moffitt Cancer and Research Institute. All subjects were within 18 months of treatment completion with surgery and adjuvant radiation and/or chemotherapy. Subjects were randomly assigned to a 6-week Mindfulness-Based Stress Reduction (MBSR) program designed to self-regulate arousal to stressful circumstances or symptoms (n = 41) or to usual care (n = 43). Outcome measures compared at 6 weeks by random assignment included validated measures of psychological status (depression, anxiety, perceived stress, fear of recurrence, optimism, social support) and psychological and physical subscales of quality of life (SF-36).Results: Compared with usual care, subjects assigned to MBSR(BC) had significantly lower (two-sided p < 0.05) adjusted mean levels of depression (6.3 vs 9.6), anxiety (28.3 vs 33.0), and fear of recurrence (9.3 vs 11.6) at 6 weeks, along with higher energy (53.5 vs 49.2), physical functioning (50.1 vs 47.0), and physical role functioning (49.1 vs 42.8). In stratified analyses, subjects more compliant with MBSR tended to experience greater improvements in measures of energy and physical functioning.Conclusions: Among BC survivors within 18 months of treatment completion, a 6-week MBSR(BC) program resulted in significant improvements in psychological status and quality of life compared with usual care. Copyright (C) 2009 John Wiley & Sons, Ltd