Characterization of the arterial anatomy of the murine hindlimb: functional role in the design and understanding of ischemia models.
Characterization of the arterial anatomy of the murine hindlimb: functional role in the design and understanding of ischemia models.
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DOI：
10.1371/journal.pone.0084047
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Kodama T
中科院分区：
文献类型：
--
作者：
Kochi T;Imai Y;Takeda A;Watanabe Y;Mori S;Tachi M;Kodama T
治疗性血管生成的成功研究需要适当的缺血模型。虽然已知先天脉管系统内存在侧支通路，但尚无描述小鼠后肢详细血管解剖结构的报道。此外，文献中解剖名称和位置描述的差异阻碍了对后肢缺血模型循环和设计的理解。为了更好地了解整个后肢的侧支循环，需要澄清后肢的所有供血动脉。本研究的目的是揭示小鼠后肢的详细动脉解剖结构和侧支通路，以便能够适当设计治疗性血管生成研究，并促进对缺血模型中循环的理解。通过对比增强 X 射线成像和手术解剖研究小鼠后肢的动脉解剖结构。观察到的解剖结构显示在照片图像和图式中。在大腿的深部、颅部和外侧部分观察到以前未被注意到但相对较大的动脉。数据表明，存在通过大腿内侧、股四头肌和股二头肌的三个侧支路线。此外，在三个供给动脉的起源处发现了解剖学变异。描述了小鼠后肢的详细动脉解剖结构和从解剖学推论的侧支路线。鉴于解剖变化，提出了缺血模型设计的限制。这些观察结果将有助于利用小鼠后肢缺血模型进行治疗性血管生成的动物研究的发展。
Appropriate ischemia models are required for successful studies of therapeutic angiogenesis. While collateral routes are known to be present within the innate vasculature, there are no reports describing the detailed vascular anatomy of the murine hindlimb. In addition, differences in the descriptions of anatomical names and locations in the literature impede understanding of the circulation and the design of hindlimb ischemia models. To understand better the collateral circulation in the whole hindlimb, clarification of all the feeding arteries of the hindlimb is required. The aim of this study is to reveal the detailed arterial anatomy and collateral routes in murine hindlimb to enable the appropriate design of therapeutic angiogenesis studies and to facilitate understanding of the circulation in ischemia models. Arterial anatomy in the murine hindlimb was investigated by contrast-enhanced X-ray imaging and surgical dissection. The observed anatomy is shown in photographic images and in a schema. Previously unnoticed but relatively large arteries were observed in deep, cranial and lateral parts of the thigh. The data indicates that there are three collateral routes through the medial thigh, quadriceps femoris, and the biceps femoris muscles. Furthermore, anatomical variations were found at the origins of the three feeding arteries. The detailed arterial anatomy of murine hindlimb and collateral routes deduced from the anatomy are described. Limitations on designs of ischemia models in view of anatomical variations are proposed. These observations will contribute to the development of animal studies of therapeutic angiogenesis using murine hindlimb ischemia models.
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影响因子：
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作者：
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通讯作者：
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DOI：
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