The tubulin code at a glance
The tubulin code at a glance
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DOI：
10.1242/jcs.199471
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发表时间：
2017-04-15
影响因子：
4
通讯作者：
Janke, Carsten
中科院分区：
文献类型：
--
作者：
Gadadhar, Sudarshan;Bodakuntla, Satish;Janke, Carsten
微管是所有真核细胞的关键细胞骨架元件，并且由进化上保守的α-微管蛋白-β-微管蛋白异二聚体组装而成。尽管微管结构均一，但其功能却多种多样。控制微管细胞骨架特化的调节机制是“微管蛋白密码”，其通过（i）不同α-和β-微管蛋白同种型的表达和（ii）微管蛋白的翻译后修饰产生。在这篇《细胞科学一瞥》文章和随附的海报中，我们提供了微管蛋白编码的分子组成的全面概述，并讨论了这些组成部分有助于产生功能特化微管的机制。
Microtubules are key cytoskeletal elements of all eukaryotic cells and are assembled of evolutionarily conserved alpha-tubulin-beta-tubulin heterodimers. Despite their uniformstructure, microtubules fulfill a large diversity of functions. A regulatory mechanism to control the specialization of the microtubule cytoskeleton is the 'tubulin code', which is generated by (i) expression of different alpha-and beta-tubulin isotypes, and by (ii) post-translational modifications of tubulin. In this Cell Science at a Glance article and the accompanying poster, we provide a comprehensive overview of the molecular components of the tubulin code, and discuss themechanisms bywhich these components contribute to the generation of functionally specialized microtubules.