Vaccination, seizures and 'vaccine damage'
Vaccination, seizures and 'vaccine damage'
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DOI：
10.1097/wco.0b013e3280555160
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发表时间：
2007-04-01
影响因子：
4.8
通讯作者：
Scheffer, Ingrid E.
中科院分区：
文献类型：
--
作者：
Brown, Natasha J.;Berkovic, Samuel F.;Scheffer, Ingrid E.
对疫苗接种安全性的担忧一直困扰着社会，疫苗接种率的降低导致流行病风险的增加。疫苗接种与发热性癫痫、“疫苗性脑病”和自闭症谱系障碍的病因有关。由于疫苗接种领域的发展，对所谓关联的评估变得复杂。本综述的重点是疫苗接种后癫痫发作的风险，以及疫苗接种与疫苗性脑病和自闭症谱系障碍之间的关联。最近的发现在过去的十年中，诸如无细胞百日咳疫苗等新疫苗的引入减少了疫苗接种后癫痫发作的发生率，即使使用旧疫苗，其结果也是良性的。2006年出现的新证据表明，所谓的“疫苗脑病”病例是由于钠通道基因的突变造成的。流行病学证据的分量不支持疫苗接种与儿童癫痫性脑病或自闭症谱系障碍之间的关系。疫苗比以往任何时候都更安全，但挑战仍然是向社会传达这一信息，从而改变对疫苗接种的态度并随后增加疫苗覆盖率。
Purpose of reviewConcerns about the safety of vaccination have plagued the community, with reduction in vaccine uptake resulting in increased risk of epidemics. Vaccination has been implicated in the cause of febrile seizures, 'vaccine encephalopathy' and autistic spectrum disorders. Evaluation of alleged associations is complicated by evolution in the vaccination field. This review focuses on the risk of seizures following vaccination and the alleged associations of vaccination with vaccine encephalopathy and also with autism spectrum disorders.Recent findingsOver the last decade the introduction of new vaccines such as the acellular pertussis vaccine has produced a reduction in seizures following vaccination, the outcome of which was benign even with older vaccines. New evidence emerged in 2006 showing that cases of alleged 'vaccine encephalopathy' are due to mutations within a sodium channel gene. The weight of epidemiological evidence does not support a relationship between vaccination and childhood epileptic encephalopathies or autism spectrum disorders.SummaryVaccines are safer than ever before, but the challenge remains to convey this message to society in such a way that produces change in attitudes to vaccination and subsequent increase in vaccine coverage.