ON THE CELLULAR SOURCE AND FUNCTION OF INTERLEUKIN-6 PRODUCED IN THE CENTRAL NERVOUS-SYSTEM IN VIRAL DISEASES
ON THE CELLULAR SOURCE AND FUNCTION OF INTERLEUKIN-6 PRODUCED IN THE CENTRAL NERVOUS-SYSTEM IN VIRAL DISEASES
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DOI：
10.1002/eji.1830190418
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发表时间：
1989-04-01
影响因子：
5.4
通讯作者：
FONTANA, A
中科院分区：
文献类型：
--
作者：
FREI, K;MALIPIERO, UV;FONTANA, A
发现感染淋巴细胞性脉络膜脑膜炎病毒(LCMV)和水泡性口炎病毒(VSV)的ICR+/+小鼠中枢神经系统(CNS)产生白介素6(IL 6)。当感染LCMV后不会出现T细胞介导性脑膜炎的裸鼠ICR nu/nu感染时，中枢神经系统未检测到明显的IL 6合成。然而，在感染了VSV的ICR nu/nu小鼠中发现了IL 6的产生，这会导致一种T细胞非依赖性的急性脑炎。提示IL-6也可能来源于不属于T细胞室的细胞。事实上，体外实验表明，病毒感染的小胶质细胞和星形胶质细胞都能分泌IL-6。在星形胶质细胞中，感染导致1.3kb的信使RNA IL-6的诱导。除了影响脑内B细胞免疫的发展外，IL-6可能参与了病毒诱导的组织损伤过程中启动的修复机制。如图所示，IL-6诱导星形胶质细胞分泌神经营养因子--神经生长因子。因此，鞘内IL 6的合成可能是宿主对感染反应的一部分，有利于免疫介导的感染性病原体的消除以及对神经元的营养支持。
Interleukin 6 (IL 6) was found to be produced in the central nervous system (CNS) of ICR +/+ mice infected with lymphocytic choriomeningitis virus (LCMV) or with vesicular stomatitis virus (VSV). When infecting athymic ICR nu/nu mice which cannot develop T cell-mediated meningitis after LCMV infection, no significant synthesis of IL 6 was detected in the CNS. IL 6 was found, however, to be produced intrathecally in ICR nu/nu mice infected with VSV, which causes a T cell-independent acute encephalitis. This suggested that IL 6 may also originate from cells not belonging to the T cell compartment. Indeed, in vitro assays showed that both virus-infected microglial cells and astrocytes secreted IL 6. In astrocytes, the infection resulted in the induction of the 1.3-kb messenger RNA IL 6. Besides its effect on the development of B cell immunity in the brain, IL 6 may be involved in repair mechanisms initiated in the course of viral-induced tissue damage. As shown here, IL 6 induced an increase of the secretion of a neurotrophic factor, nerve growth factor by astrocytes. Thus, the intrathecal synthesis of IL 6 may be part of the host response to infection favoring immune-mediated elimination of the infectious agent as well as trophic support for neurons.