Mobile introns and intron-encoded proteins.

Mobile introns and intron-encoded proteins.
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移动内含子和内含子编码的蛋白质。

DOI:
10.1126/science.2479980
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发表时间:
1989
期刊:
Science (New York, N.Y.)
影响因子:
--
通讯作者:
Butow,RA
Butow,RA
中科院分区:
--
文献类型:
--
作者:
Perlman,PS;Butow,RA

文献摘要

被引文献

相似文献

通常认为真核生物核基因组中的分裂基因是由外显子改组过程产生的(1)。一旦形成,中间序列将可以在没有直接选择压力的情况下自由进化,形成它们的祖先不再识别(或几乎不识别)的形式。在这篇文章中,我们回顾和讨论了最近发现的一类相关内含子元件的定向插入的一些意义。这些新数据增加了内含子移动性是分裂基因的另一个来源的可能性。
T IS GENERALLY BELIEVED THAT SPLIT GENES IN THE NUCLEAR genomes of eukaryotes arose by a process ofexon shuffling (1). Once formed, the intervening sequences would be free to evolve in the absence of direct selection pressures to forms no longer recognizable (or barely so) from their progenitors. In this perspec-tive, we review and discuss some implications of recent findings of directed insertion of a class of related intron elements. These new data raise the likelihood that intron mobility was another source of split genes.