Superlattice stacking by hybridizing layered double hydroxide nanosheets with layers of reduced graphene oxide for electrochemical simultaneous determination of dopamine, uric acid and ascorbic acid
Superlattice stacking by hybridizing layered double hydroxide nanosheets with layers of reduced graphene oxide for electrochemical simultaneous determination of dopamine, uric acid and ascorbic acid
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通过将层状双氢氧化物纳米片与还原氧化石墨烯层杂化进行超晶格堆叠，用于电化学同时测定多巴胺、尿酸和抗坏血酸
DOI：
10.1007/s00604-018-3158-y
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发表时间：
2019-02-01
影响因子：
5.7
通讯作者：
Liu, Hongfang
中科院分区：
文献类型：
--
作者：
Asif, Muhammad;Aziz, Ayesha;Liu, Hongfang
通过集成带正电的 Zn-NiAl 层状双氢氧化物 (LDH) 半导体片和带负电的还原氧化石墨烯 (rGO) 层，获得了自组装周期性超晶格材料。该材料用于修饰玻碳电极，该电极被证明是一种可行的传感器，用于诊断参数多巴胺 (DA)、尿酸 (UA) 和抗坏血酸 (AA)。修饰后的 GCE 对这些生物分子表现出优异的电催化活性。这被认为是由于以下因素的协同效应：(a) 导电 rGO 直接邻近 LDH 的半导体通道而赋予优异的界面导电性；(b) LDH 优异的插层特性；(c) 具有大量活性位点的扩大表面。该生物传感器在选择性、灵敏度和宽线性范围方面表现出出色的电化学性能。与饱和甘汞电极相比，通常在 -0.10、+0.13 和 ++0.27 V 的工作电位下工作，AA、DA 和 UA 的检测下限分别为 13.5 nM、0.1 nM 和 0.9 nM，信噪比为 3。该传感器用于实时跟踪活人的多巴胺流出图文摘要通过将带正电的 Zn-NiAl 层状双氢氧化物 (LDH) 半导体片与带负电的还原氧化石墨烯 (rGO) 层集成来制备超晶格自组装材料的示意图。应用于同时电化学检测多巴胺（DA）、尿酸和抗坏血酸。
A self-assembled periodic superlattice material was obtained by integrating positively charged semiconductive sheets of a Zn-NiAl layered double hydroxide (LDH) and negatively charged layers of reduced graphene oxide (rGO). The material was used to modify a glassy carbon electrode which then is shown to be a viable sensor for the diagnostic parameters dopamine (DA), uric acid (UA) and ascorbic acid (AA). The modified GCE displays excellent electrocatalytic activity towards these biomolecules. This is assumed to be due to the synergistic effects of (a) excellent interfacial electrical conductivity that is imparted by direct neighboring of conductive rGO to semiconductive channels of LDHs, (b) the superb intercalation feature of LDHs, and (c) the enlarged surface with an enormous number of active sites. The biosensor revealed outstanding electrochemical performances in terms of selectivity, sensitivity, and wide linear ranges. Typically operated at working potentials of −0.10, +0.13 and + 0.27 V vs. saturated calomel electrode, the lower detection limits for AA, DA and UA are 13.5 nM, 0.1 nM, and 0.9 nM, respectively, at a signal-to-noise ratio of 3. The sensor was applied to real-time tracking of dopamine efflux from live human nerve cells.Graphical abstractSchematic of the preparation of a superlattice self-assembled material by integrating positively charged semiconductive sheets of Zn-NiAl layered double hydroxide (LDH) with negatively charged reduced graphene oxide (rGO) layers. It was applied to simultaneous electrochemical detection of dopamine (DA), uric acid and ascorbic acid.