Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction
Major racial differences in coronary constrictor response between Japanese and Caucasians with recent myocardial infarction
复制标题
DOI：
10.1161/01.cir.101.10.1102
复制
发表时间：
2000-03-14
期刊：
影响因子：
37.8
通讯作者：
Maseri, A
中科院分区：
文献类型：
--
作者：
Pristipino, C;Beltrame, JF;Maseri, A
背景：心肌梗死（AMI）急性期冠状动脉血管运动增强可能导致急性冠状动脉闭塞。日本人有较高的变异型心绞痛的发病率比高加索患者，但在AMI后早期血管反应性的种族差异是有争议的。方法和结果-同一小组研究了15个日本人和19个高加索患者在14天内AMI的乙酰胆碱注射到非梗死相关（NIRA）和梗死相关（伊拉）冠状动脉，然后硝酸甘油。通过定量血管造影术评估了每次药物推注后近端、中间和远端节段的血管舒张、血管收缩、痉挛和基础张力的发生率。日本患者的胆固醇水平远低于白人（183 +/- 59 vs 247 +/- 53 mg/dL，P
Background-Enhanced coronary vasomotion may contribute to acute coronary occlusion during the acute phase of myocardial infarction (AMI). Japanese have a higher incidence of variant angina than Caucasian patients, but racial differences in vasomotor reactivity early after AMI are controversial.Methods and Results-The same team studied 15 Japanese and 19 Caucasian patients within 14 days of AMI by acetylcholine injection into non-infarct-related (NIRA) and infarct-related (IRA) coronary arteries followed by nitroglycerin. Incidence of vasodilation, vasoconstriction, spasm, and basal tone were assessed in proximal, middle, and distal segments after each drug bolus by quantitative angiography, Japanese patients had much lower cholesterol levels than Caucasians (183 +/- 59 versus 247 +/- 53 mg/dL, P