Sorting and assembly of mitochondrial outer membrane proteins
Sorting and assembly of mitochondrial outer membrane proteins
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DOI：
10.1016/j.bbabio.2008.03.017
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发表时间：
2008-07-01
影响因子：
4.3
通讯作者：
Meisinger, Chris
中科院分区：
文献类型：
--
作者：
Becker, Thomas;Voegtle, F. Nora.;Meisinger, Chris
在过去的几年里，就新成分和新的分选途径而言，蛋白质输入线粒体的情况变得更加复杂。这些新的发现也改变了关于线粒体外膜蛋白生物合成途径的观点。除了锚定有跨膜α-螺旋的蛋白质之外，线粒体的内共生起源导致在该隔室中存在跨膜β-桶。外膜蛋白的分选和组装途径涉及三种机制：外膜移位酶（TOM复合物）、分选和组装机制（SAM复合物）和MDM复合物（线粒体分布和形态）。在这里，我们回顾了最近的事态发展外膜蛋白的生物合成途径，重点是汤姆蛋白，这些前体蛋白的研究最深入的类。(C)2008 Elsevier B. V.保留所有权利。
In the last years the picture of protein import into the mitochondria has become much more complicated in terms of new components and new sorting pathways. These novel findings have also changed views concerning the biogenesis pathway of mitochondrial outer membrane proteins. In addition to proteins anchored with transmembrane alpha-helices, the endosymbiotic origin of the mitochondria has resulted in the presence of transmembrane beta-barrels in this compartment. The sorting and assembly pathway of outer membrane Proteins involves three machineries: the translocase of the outer membrane (TOM complex) the sorting and assembly machinery (SAM complex) and the MDM complex (mitochondrial distribution and morphology). Here we review recent developments on the biogenesis pathways of outer membrane proteins with a focus on Tom proteins, the most intensively studied class of these precursor proteins. (C) 2008 Elsevier B.V. All rights reserved.