Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats
Effects of cilnidipine on sympathetic outflow and sympathetic arterial pressure and heart rate regulations in rats
复制标题
西尼地平对大鼠交感神经流出及交感动脉压和心率调节的影响
DOI：
10.1016/j.lfs.2013.05.004
复制
发表时间：
2013
期刊：
影响因子：
6.1
通讯作者：
Sugimachi M
中科院分区：
文献类型：
--
作者：
Yamamoto H;Kawada T;Shimizu S;Kamiya A;Miyazaki S;Sugimachi M
AIMSCilnidipine是一种独特的钙通道阻滞剂，可抑制L型和N型钙通道。本研究旨在评估静脉注射西尼地平对交感神经流出和交感动脉压（AP）和心率（HR）regulation.MAIN METHODS的影响颈动脉窦压力感受器区分离的麻醉和迷走神经切断的Wistar京都大鼠的体循环。在静脉注射西尼地平之前和期间，检测传出交感神经活动（SNA）、AP和HR对颈动脉窦压力阶跃输入的反应的变化（30μg/kg推注+100μ g kg − 1 h − 1输注，n=6）。关键发现西尼地平显著降低AP反应范围（从68.0±10.2到34.6±4.1mmHg，P=0.007），但不影响SNA反应范围（从90.4± 10.3%至84.7± 9.5%，P=0.297）或HR反应范围（从50.4±10.1到48.1± 6.2次/分，P=0.719）。不会剧烈抑制交感神经从中枢神经系统流出。此外，它还保留了交感HR反应，表明在心脏交感神经末梢的N型Ca 2+通道阻断作用可能是适度的。
AIMSCilnidipine is a unique Ca2+channel blocker that inhibits both L-type and N-type Ca2+channels. The present study aimed to assess the effects of intravenous cilnidipine on sympathetic outflow and sympathetic arterial pressure (AP) and heart rate (HR) regulations.MAIN METHODSCarotid sinus baroreceptor regions were isolated from the systemic circulation in anesthetized and vagotomized Wistar Kyoto rats. Changes in efferent sympathetic nerve activity (SNA), AP and HR in response to a stepwise input of carotid sinus pressure were examined before and during intravenous cilnidipine administration (30μg/kg bolus+100μgkg−1h−1infusion, n=6).KEY FINDINGSCilnidipine significantly reduced the AP response range (from 68.0±10.2 to 34.6±4.1mmHg, P=0.007) but did not affect the SNA response range (from 90.4±10.3 to 84.7±9.5%, P=0.297) or the HR response range (from 50.4±10.1 to 48.1±6.2beats/min, P=0.719).SIGNIFICANCECilnidipine, at a depressor dose used in the present study, does not acutely suppress sympathetic outflow from the central nervous system. Also, it spared the sympathetic HR response, suggesting that N-type Ca2+channel blocking action at the cardiac sympathetic nerve endings may be a modest one.