Rigorous control conditions diminish treatment effects in weight loss-randomized controlled trials.
Rigorous control conditions diminish treatment effects in weight loss-randomized controlled trials.
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DOI：
10.1038/ijo.2015.212
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发表时间：
2016-06
期刊：
影响因子：
--
通讯作者：
Allison DB
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文献类型：
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作者：
Dawson JA;Kaiser KA;Affuso O;Cutter GR;Allison DB
It has not been established whether control conditions with large weight losses (WLs) diminish expected treatment effects in WL or prevention of weight gain (PWG) randomized controlled trials (RCTs). We performed a meta-analysis of 239 WL/PWG RCTs that include a control group and at least one treatment group. A maximum likelihood meta-analysis framework is used in order to model and understand the relationship between treatment effects and control group outcomes. Under the informed model, an increase in control group WL of one kilogram corresponds with an expected shrinkage of the treatment effect by 0.309 kg [95% CI (−0.480, −0.138), p = 0.00081]; this result is robust against violations of the model assumptions. We find that control conditions with large weight losses diminish expected treatment effects. Our investigation may be helpful to clinicians as they design future WL/PWG studies.
