Palladium Catalyzed Decarboxylative Rearrangement of N-Alloc Indoles
Palladium Catalyzed Decarboxylative Rearrangement of N-Alloc Indoles
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DOI：
10.1021/ol400110c
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发表时间：
2013-03-01
期刊：
影响因子：
5.2
通讯作者：
Cook, Matthew J.
中科院分区：
文献类型：
--
作者：
Chen, Jun;Cook, Matthew J.
本文报道了钯催化的烯丙基重排反应。这也可以在单锅转化中与Suzuki-Miyaura交叉偶联反应组合。取代的alloc基团和苄基变体也已被证明与有前途的对映体选择性变体的初步结果。
A highly efficient palladium catalyzed decarboxylative allylic rearrangement of alloc indoles has been developed. This can also be combined with a Suzuki-Miyaura cross-coupling reaction in a single pot transformation. Substituted alloc groups and benzylic variants have also been demonstrated alongside promising initial results on the enantioselective variant.