Role of Adipokines and Cytokines in Non-alcoholic Fatty Liver Disease
Role of Adipokines and Cytokines in Non-alcoholic Fatty Liver Disease
复制标题
DOI：
10.2174/1574887109666141216102458
复制
发表时间：
2014-01-01
影响因子：
1.9
通讯作者：
Peta, Valentina
中科院分区：
文献类型：
--
作者：
Abenavoli, Ludovico;Peta, Valentina
代谢综合征最常见的肝脏表现之一是非酒精性脂肪肝（NAFLD）。这种疾病从单纯的脂肪变性到肝硬化和肝细胞癌不等。脂肪组织分泌的脂联素、瘦素、抵抗素、内脏素等不同分子和促炎细胞因子如肿瘤坏死因子- α、白细胞介素等可能参与NAFLD的发病。在这篇综述中，我们描述了这些脂肪因子和细胞因子在NAFLD发病中的作用。我们评论了它们作为脂肪变性和纤维化的非侵入性生物标志物的潜在用途，以及它们潜在的治疗作用。
One of the most common hepatic manifestations of the metabolic syndrome is non-alcoholic fatty liver disease (NAFLD). This disease varies from simple steatosis to cirrhosis and hepatocellular carcinoma. Different molecules secreted from adipose tissue such as adiponectin, leptin, resistin and visfatin and pro-inflammatory cytokines such as tumour necrosis factor-alpha, and interleukins, can be involved in the pathogenesis of NAFLD. In this review we describe the role of these adipokines and cytokines in the pathogenesis of NAFLD. We comment on their potential use as non-invasive biomarkers of steatosis and fibrosis, and their potential therapeutic role.