SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins.
SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins.
复制标题
DOI：
--
复制
发表时间：
1994-04
期刊：
影响因子：
8
通讯作者：
S. A. Jankowski;D. Mitchell;Sharon Smith;J. Trent;P. Meltzer
中科院分区：
文献类型：
--
作者：
S. A. Jankowski;D. Mitchell;Sharon Smith;J. Trent;P. Meltzer
12q13-14的扩增发生在包括恶性纤维组织细胞瘤和脂肪肉瘤在内的人类肉瘤亚群中。该染色体区域先前已被发现包含许多生长相关基因，包括GLI原癌基因和p53相关蛋白MDM2。我们现在报道SAS（肉瘤扩增序列）的特征，这是在该区域发现的一种新的转录物。序列分析表明，SAS是跨膜蛋白家族（跨膜4超家族或TM4SF）的新成员，被认为参与生长相关的细胞过程。这一观察结果将TM4SF蛋白添加到人类肉瘤中经常扩增的12q13-14基因簇中。
Amplification of 12q13-14 occurs in a subset of human sarcomas including malignant fibrous histiocytoma and liposarcoma. This chromosomal region has previously been found to include a number of growth-related genes including the GLI proto-oncogene and the p53-associated protein, MDM2. We now report the characterization of SAS (sarcoma amplified sequence), a novel transcript found in this region. Sequence analysis demonstrates that SAS is a novel member of a transmembrane protein family (transmembrane 4 superfamily or TM4SF) thought to be involved in growth-related cellular processes. This observation adds a TM4SF protein to the cluster of genes at 12q13-14 frequently amplified in human sarcomas.