DIFFERENTIAL RATES OF FORGETTING FROM LONG-TERM-MEMORY IN ALZHEIMERS AND MULTIINFARCT DEMENTIA
DIFFERENTIAL RATES OF FORGETTING FROM LONG-TERM-MEMORY IN ALZHEIMERS AND MULTIINFARCT DEMENTIA
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DOI：
10.3109/00207459308987206
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发表时间：
1993-01-01
影响因子：
2.2
通讯作者：
CALTAGIRONE, C
中科院分区：
文献类型：
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作者：
CARLESIMO, GA;FADDA, L;CALTAGIRONE, C
在这项研究中，我们探索了阿尔茨海默氏症(AD)和多发性脑梗塞(MID)痴呆症患者长期记忆的健忘率。为此，我们对15名AD、15名MID和22名对照受试者进行了两项任务，分别探索长期言语记忆和长期视觉空间记忆。两项任务中的绝对健忘率计算为立即回忆备忘录和延迟回忆备忘录之间的差异。由于即时回忆的水平在不同组之间有显著差异，因此计算了每个患者的比例遗忘比率(从立即回忆到延迟回忆的备忘录丢失百分比)。在言语任务中(雷伊的15个单词)。AD组的遗忘绝对率和遗忘比例显著高于MID组和对照组。在空间任务(Corsi块上)中，不同组之间的绝对健忘率只有轻微的差异。然而，AD患者表现出比MID和正常受试者更大的遗忘比例。这些结果指出，AD患者的长期记忆存储中的信息急剧衰退。根据以前的数据(Corkin等人，1984；Kopelman，1985)，我们提出AD的长期记忆缺陷至少部分是由于在获得后的最初几分钟内的异常遗忘信息。在接下来的时间段(10分钟到几天)仍然存在的信息被正常保留。MID患者的正常健忘率进一步表明，血管性痴呆和退行性痴呆记忆障碍的潜在机制不同。
In this study we explored the rate of forgetting from long-term memory in Alzheimer's (AD) and multiinfarct (MID) dementia. For this purpose, we administered to 15 AD, 15 MID, and 22 control subjects two tasks exploring, respectively, long-term verbal and long-term visuo-spatial memory. The absolute rate of forgetting in both tasks was computed as the difference between immediate and delayed recall of memorandum. Since level of immediate recall was significantly different between groups, a proportional rate of forgetting (percentage of memorandum lost passing from immediate to delayed recall) was computed for each patient. In the verbal task (Rey's 15 words). AD patients displayed significantly larger absolute and proportional rates of forgetting than MID and control subjects. In the spatial task (Corsi block supraspan), the absolute rate of forgetting was only marginally different between groups. Nevertheless, AD patients demonstrated a larger proportional rate of forgetting than MID and normal subjects. These results point out an exalted decay of information from long-term memory store in AD patients. In the light of previous data (Corkin et al., 1984; Kopelman, 1985) we propose that long-term memory deficits in AD is due, at least in part, to an abnormal forgetting of information within the first few minutes following acquisition. Information still present in the subsequent period (10 min to several days) is retained normally. The normal rate of forgetting in MID patients, further, suggests different mechanisms underlying memory disorders in vascular and degenerative dementias.