Effects of increasing temperatures on biomarker responses and accumulation of hazardous substances in rope mussels (Mytilus galloprovincialis) from Bizerte lagoon
Effects of increasing temperatures on biomarker responses and accumulation of hazardous substances in rope mussels (Mytilus galloprovincialis) from Bizerte lagoon
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温度升高对比塞大泻湖绳状贻贝 (Mytilus galloprovincialis) 生物标志物反应和有害物质积累的影响
DOI：
10.1007/s11356-014-2540-5
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发表时间：
2014
影响因子：
5.8
通讯作者：
H. Boussetta
中科院分区：
文献类型：
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作者：
N. Kamel;T. Burgeot;M. Banni;Mohamed Chalghaf;S. Devin;C. Minier;H. Boussetta
本研究探讨了春季和夏季温度升高对采自突尼斯北方比泽尔特泻湖（Bizerte lagoon）的贻贝（Mytilus galloprovincialismussels）生物化学标志物的影响。在电池的7个生物标志物的空间和季节变化进行了分析有关的环境参数（温度，盐度和pH值），生理状态（条件和性腺指数），应力应力（SoS），和化学污染物水平（重金属，多环芳烃（PAHs），和多氯联苯）在消化腺。综合生物反应（IBR）计算使用7个生物标志物（乙酰胆碱酯酶（AChE），苯并[a]芘羟化酶（BPH），多异源生物素抗性（MXR），谷胱甘肽S-转移酶（GST），过氧化氢酶（CAT），丙二醛（MDA），金属硫蛋白（MT）。生物反应的季节性变化，确定在春季和夏季之间的关键时期，在两个网站，化学污染变化的因素为2的重金属和多环芳烃的因素2.5。对一组生物标志物的分析与两个地点的生理参数的测量相结合，以量化5月至8月之间温度升高11 °C时代谢调节的最大范围。根据我们的研究结果，MT，MDA，CAT和AChE生物标志物在11 °C上升期间显示出最高幅度，而BPH，GST和MXR生物标志物显示出最低幅度。在污染最严重的Menzel Abdelrahmen站用IBR测量的代谢幅度显示，8月份比泽尔特泻湖的代谢压力最高，当时温度最高为29.1 °C。这种高代谢率在北非泻湖地区的每个生物标志物进行了量化，并在8月得到证实，当最高的IBR指数值在污染最轻的网站2（IBR = 9.6）和污染最严重的网站1（IBR = 19.6）。化学污染和增加的盐度和温度在夏季的综合影响似乎诱导最高的代谢适应反应，因此可以用来确定阈值的有效性和促进监测生物标志物的解释。这种方法，适用于在两个站点的温度大幅上升，不同的化学污染，是确定在北非泻湖的环境评估标准（EAC）阈值的第一步。
This study examined the influence of increasing temperatures in spring and summer on biochemical biomarkers inMytilus galloprovincialismussels sampled from Bizerte lagoon (northern Tunisia). Spatial and seasonal variations in a battery of seven biomarkers were analyzed in relation to environmental parameters (temperature, salinity, and pH), physiological status (condition and gonad indexes), stress on stress (SoS), and chemical contaminant levels (heavy metals, polycyclic aromatic hydrocarbons (PAHs), and PCBs) in digestive glands. Integrated biological response (IBR) was calculated using seven biomarkers (acetylcholinesterase (AChE), benzo[a]pyrene hydroxylase (BPH), multixenobiotic resistance (MXR), glutathione S-transferase (GST), catalase (CAT), malondialdehyde (MDA), and metallothioneins (MT). Seasonal variations in biological response were determined during a critical period between spring and summer at two sites, where chemical contamination varies by a factor of 2 for heavy metals and a factor 2.5 for PAHs. The analysis of a battery of biomarkers was combined with the measurement of physiological parameters at both sites, in order to quantify a maximum range of metabolic regulation with a temperature increase of 11 °C between May and August. According to our results, the MT, MDA, CAT, and AChE biomarkers showed the highest amplitude during the 11 °C rise, while the BPH, GST, and MXR biomarkers showed the lowest amplitude. Metabolic amplitude measured with the IBR at Menzel Abdelrahmen—the most severely contaminated station—revealed the highest metabolic stress in Bizerte lagoon in August, when temperatures were highest 29.1 °C. This high metabolic rate was quantified for each biomarker in the North African lagoon area and confirmed in August, when the highest IBR index values were obtained at the least contaminated site 2 (IBR = 9.6) and the most contaminated site 1 (IBR = 19.6). The combined effects of chemical contamination and increased salinity and temperatures in summer appear to induce a highest metabolic adaptation response and can therefore be used to determine thresholds of effectiveness and facilitate the interpretation of monitoring biomarkers. This approach, applied during substantial temperature increases at two sites with differing chemical contamination, is a first step toward determining an environmental assessment criteria (EAC) threshold in a North African lagoon.
“小鼠髓磷脂碱性蛋白基因的启动子元件在 NG108-15 神经元/神经胶质细胞基因中有效发挥作用。”
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