Glycemic index, glycemic load, and pancreatic cancer risk (Canada)
Glycemic index, glycemic load, and pancreatic cancer risk (Canada)
复制标题
DOI：
10.1007/s10552-004-5028-7
复制
发表时间：
2005-05-01
影响因子：
2.3
通讯作者：
Miller, AB
中科院分区：
文献类型：
--
作者：
Silvera, SAN;Rohan, TE;Miller, AB
有一些证据表明血浆胰岛素和负荷后血浆葡萄糖可能与胰腺癌的风险相关。血糖指数和血糖负荷是一种测量方法，可以根据餐后血糖的影响及其对循环胰岛素水平的影响对各种食物的碳水化合物含量进行分类。因此，我们在一个由 49,613 名参加国家乳腺筛查研究 (NBSS) 的加拿大女性组成的前瞻性队列中检查了胰腺癌风险与血糖指数 (GI)、血糖负荷 (GL) 以及膳食碳水化合物和糖摄入量的关系，这些女性在 1980 年至 1985 年间完成了自我管理的食物频率调查问卷。与国家癌症和死亡率数据库的链接产生了数据 关于癌症发病率和死亡的调查，随访结束于 1998 年至 2000 年。在平均 16.5 年的随访期间，我们观察到了 112 例胰腺癌病例。总体血糖指数、血糖负荷、总碳水化合物和总糖摄入量与胰腺癌风险之间没有关联。在多变量调整模型中，总体 GI 和 GL 最高与最低四分位水平的风险比 (HR) 分别为 1.43（95% 置信区间 [CI]=0.56-3.65，P 趋势=0.58）和 0.80（95% CI=0.45-1.41，P 趋势=0.41）。我们的数据表明，总体血糖指数和血糖负荷以及总糖和总碳水化合物摄入量与胰腺癌风险无关。然而，鉴于有关饮食在胰腺癌病因学中的作用的文献有限，特别是在血糖指数/负荷方面，有必要进行进一步的研究。
There is some evidence that plasma insulin and postload plasma glucose may be associated with risk of pancreatic cancer. Glycemic index and glycemic load are measures, which allow the carbohydrate content of individual foods to be classified according to their postprandial glycemic effects and hence their effects on circulating insulin levels. Therefore, we examined pancreatic cancer risk in association with glycemic index (GI), glycemic load (GL), and intake of dietary carbohydrate and sugar in a prospective cohort of 49,613 Canadian women enrolled in the National Breast Screening Study (NBSS) who completed a self-administered food frequency questionnaire between 1980 and 1985. Linkages to national cancer and mortality databases yielded data on cancer incidence and deaths, with follow-up ending between 1998 and 2000. During a mean 16.5 years of follow-up, we observed 112 incident pancreatic cancer cases. There was no association between overall glycemic index, glycemic load, total carbohydrate and total sugar intake and pancreatic cancer risk. In multivariate adjusted models, the hazard ratio (HR) for the highest versus lowest quartile levels of overall GI and GL were 1.43 (95% confidence interval [CI]=0.56-3.65, P-trend=0.58) and 0.80 (95% CI=0.45-1.41, P-trend=0.41), respectively. Our data suggest that overall glycemic index and glycemic load, as well as total sugar and total carbohydrate intake, are not associated with pancreatic cancer risk. However, given the limited literature regarding the role of diet in the etiology of pancreatic cancer, particularly with respect to glycemic index/load, further investigation is warranted.