Pathophysiology of a severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant
Pathophysiology of a severe case of Puumala hantavirus infection successfully treated with bradykinin receptor antagonist icatibant
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DOI：
10.1016/j.antiviral.2014.08.007
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发表时间：
2014-11-01
影响因子：
7.6
通讯作者：
Mustonen, Jukka
中科院分区：
文献类型：
--
作者：
Vaheri, Antti;Strandin, Tomas;Mustonen, Jukka
我们最近描述了一个非常严重的普马拉汉坦病毒感染的毛细血管渗漏综合征和休克表现的病人。他用缓激肽受体拮抗剂艾替班特（Antonen et al.，2013年）的报告。在这里，我们报告的病理生理学分析表明，明显的补体激活，延长白细胞增多，广泛的纤维蛋白溶解，循环组蛋白和肝功能的缺陷。患者具有罕见的HLA表型，这可能导致了疾病的严重病程。(C)2014爱思唯尔有限公司版权所有。
We recently described a patient with very severe Puumala hantavirus infection manifested by capillary leakage syndrome and shock. He was successfully treated with the bradykinin receptor antagonist, icatibant (Antonen et al., 2013). Here we report analysis of the pathophysiology which indicated pronounced complement activation, prolonged leukocytosis, extensive fibrinolysis, circulating histones, and defects in liver function. The patient had an uncommon HLA-phenotype, which may have contributed to the severe course of the disease. (C) 2014 Elsevier B.V. All rights reserved.