Regulation of the gain of visually guided smooth-pursuit eye movements by frontal cortex
Regulation of the gain of visually guided smooth-pursuit eye movements by frontal cortex
复制标题
额叶皮层视觉引导平滑追踪眼动增益的调节
DOI：
10.1038/35051582
复制
发表时间：
2001
期刊：
影响因子：
64.8
通讯作者：
S. Lisberger
中科院分区：
文献类型：
--
作者：
Masaki Tanaka;S. Lisberger
在引起行为的神经机制的研究中，给定刺激产生的神经和行为反应的变化已被广泛报道。这种“增益控制”可以增强对特别相关的感官输入的反应，在运动神经元执行的反射中进行选择或强调特定的运动目标。增益控制也是平滑追踪眼动系统的一个组成部分。增益控制的一个特征是，在注视期间对静止目标的短暂扰动会导致微小的眼球运动，而在精确追踪的活动状态期间对移动目标的相同扰动会引起较大的响应。在这里，我们展示了对额叶弓状沟中的平滑追踪眼球运动区域（“额叶追踪区域”，FPA）的电刺激模仿了追踪的活跃状态。无论运动方向如何，这种刺激都会增强对目标运动短暂扰动的响应。我们假设FPA设定追踪增益，从而参与追踪的目标选择。
In studies of the neural mechanisms giving rise to behaviour, changes in the neural and behavioural responses produced by a given stimulus have been widely reported. This ‘gain control’ can boost the responses to sensory inputs that are particularly relevant, select among reflexes for execution by motoneurons or emphasize specific movement targets. Gain control is also an integral part of the smooth-pursuit eye movement system. One signature of gain control is that a brief perturbation of a stationary target during fixation causes tiny eye movements, whereas the same perturbation of a moving target during the active state of accurate pursuit causes large responses. Here we show that electrical stimulation of the smooth-pursuit eye movement region in the arcuate sulcus of the frontal lobe (‘the frontal pursuit area’, FPA) mimics the active state of pursuit. Such stimulation enhances the response to a brief perturbation of target motion, regardless of the direction of motion. We postulate that the FPA sets the gain of pursuit, thereby participating in target selection for pursuit.
灵长类动物额眼区域内蝇蕈醇失活后，平滑追踪眼球运动出现缺陷。
DOI：
10.1152/jn.1998.80.1.458
发表时间：
1998
期刊：
Journal of neurophysiology.
影响因子：
--
作者：
Shi,D;Friedman,HR;Bruce,CJ
通讯作者：
Bruce,CJ
影响因子：
2.5
作者：
GRASSE, KL;LISBERGER, SG
通讯作者：
LISBERGER, SG
影响因子：
2.5
作者：
GOTTLIEB, JP;MACAVOY, MG;BRUCE, CJ
通讯作者：
BRUCE, CJ