Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania.
Prediction of metabolic syndrome by low serum testosterone levels in men: results from the study of health in Pomerania.
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DOI：
10.2337/db09-0031
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发表时间：
2009-09
期刊：
影响因子：
7.7
通讯作者：
Wallaschofski H
中科院分区：
文献类型：
--
作者：
Haring R;Völzke H;Felix SB;Schipf S;Dörr M;Rosskopf D;Nauck M;Schöfl C;Wallaschofski H
本分析的目的是评估血清睾酮和硫酸脱氢表雄酮（DHEAS）水平与男性代谢综合征（MetS）的前瞻性关联。数据来自波美拉尼亚健康研究（SHIP），这是一项基于人群的前瞻性队列研究，年龄在20-79岁之间。对1,004名无基线代谢综合征的男性进行了分析，这些男性的基线代谢综合征由国家胆固醇教育计划成人治疗小组III指南定义。通过年龄特异性四分位数和Poisson回归模型对替吉奥和DHEAS进行分类，估计相对风险（RR）和95% CI。在中位随访时间为5.0年后，480名男性（47.8%）发展为MetS。随着MetS组分数量的增加，睾酮水平降低。在最低的四分位数中，Tehrine预测MetS（RR 1.38 [95% CI 1.13-1.69]），特别是在20-39岁的男性中（2.06 [1.29-3.29]），即使在校正了年龄、吸烟、饮酒、体力活动、腰围、自我相关健康和采血时间后。DHEAS水平与MetS事件无关（0.99 [0.83-1.19]）。低睾酮而不是DHEAS预测代谢综合征的发展，在一个以人群为基础的队列的1,004名男性年龄在20-79岁。特别是在20-39岁的年轻男性中，结果表明低睾酮是MetS事件的强有力预测因素。评估青年和中年男性的睾酮水平可能有助于对一般人群进行早期干预。
The aim of this analysis was to assess the prospective association of serum testosterone and dehydroepiandrosterone sulfate (DHEAS) levels with incident metabolic syndrome (MetS) in men. Data were obtained from the Study of Health in Pomerania (SHIP), a population-based prospective cohort of adults aged 20–79 years. Analyses were conducted in 1,004 men without baseline MetS defined by National Cholesterol Education Program Adult Treatment Panel III guidelines. Testosterone and DHEAS were categorized by age-specific quartiles and Poisson regression models with relative risks (RRs) and 95% CIs were estimated. After a median follow-up time of 5.0 years, 480 men (47.8%) developed MetS. Testosterone levels decreased with increasing number of MetS components. Testosterone in the lowest quartile predicted MetS (RR 1.38 [95% CI 1.13–1.69]), particularly among men aged 20–39 years (2.06 [1.29–3.29]), even after adjustment for age, smoking, alcohol consumption, physical activity, waist circumference, self-related health, and time of blood sampling. DHEAS levels were not related to incident MetS (0.99 [0.83–1.19]). Low testosterone but not DHEAS predicts development of MetS in a population-based cohort of 1,004 men aged 20–79 years. Especially in young men aged 20–39 years, results suggest low testosterone as a strong predictor for incident MetS. Assessment of testosterone in young and middle-age men may allow early interventions in the general population.