Leukocyte telomere length dynamics in women and men: menopause vs age effects
Leukocyte telomere length dynamics in women and men: menopause vs age effects
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DOI：
10.1093/ije/dyv165
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发表时间：
2015-10-01
影响因子：
7.7
通讯作者：
Aviv, Abraham
中科院分区：
文献类型：
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作者：
Dalgard, Christine;Benetos, Athanase;Aviv, Abraham
背景资料：一个较长的白细胞端粒长度（LTL）的女性比男性已被归因于一个缓慢的LTL磨损率的妇女，也许是由于高雌激素暴露在绝经前periods.Methods：为了测试这个前提，我们进行了一项纵向研究（平均随访12年）在一个子集的人口为基础的丹麦国家双胞胎登记。参与者包括405名妇女，年龄37.5岁，（范围18.0 - 64.3）岁，329名男性，年龄38.8结果：女性的LTL [kb +/-标准误（SE）]比男性长（基线：7.01 ± 0.03 vs 6.87 ± 0.04;随访：6.79 ± 0.03 vs 6.65 ± 0.03;均P = 0.005）。女性从绝经前（20.6 +/-1.0）到绝经期（16.5 +/-1.3）再到绝经后（15.1 +/-1.7），LTL损耗（bp/年+/-SE）减速。对绝经状态进行统计学控制后，年龄与女性LTL损耗无关。与此相反，男性表现出年龄依赖性的增长率的LTL的摩擦，这与女性的模式显着不同（P的相互作用= 0.01）。结论：结果表明，绝经前的时期是表示在一个较高的比率LTL的摩擦比绝经后的时期。他们进一步表明，LTL的性别差距源于早期的年龄-生长和发育时期。我们认为绝经前妇女LTL损耗率较高可能与雌激素介导的红细胞更新增加、月经出血或两者兼而有之有关。
Background: A longer leukocyte telomere length (LTL) in women than men has been attributed to a slow rate of LTL attrition in women, perhaps due to high estrogen exposure during the premenopausal period.Methods: To test this premise we performed a longitudinal study (an average follow-up of 12 years) in a subset of the population-based Danish National Twin Registry. Participants consisted of 405 women, aged 37.5 (range 18.0-64.3) years, and 329 men, aged 38.8 (range 18.0-58.5) years, at baseline examination.Results: Women showed a longer LTL [kb +/- standard error(SE)] than men (baseline: 7.01 +/- 0.03 vs 6.87 +/- 0.04; follow-up: 6.79 +/- 0.03 vs 6.65 +/- 0.03; both P = 0.005). Women displayed deceleration of LTL attrition (bp/years +/- SE), as they transitioned from the premenopausal period (20.6 +/- 1.0) through the perimenopausal period (16.5 +/- 1.3) to the postmenopausal period (15.1 +/- 1.7). Age was not associated with LTL attrition in women after statistical control for menopausal status. Men, in contrast, displayed a trend for age-dependent increase in the rate of LTL attrition, which differed significantly from the pattern in women (P for interaction = 0.01).Conclusions: Results indicate that the premenopausal period is expressed in a higher rate of LTL attrition than the postmenopausal period. They further suggest that the sex gap in LTL stems from earlier ages-the period of growth and development. The higher rate of LTL attrition in premenopausal women, we propose, might relate to estrogen-mediated increased turnover of erythrocytes, menstrual bleeding or both.