The perirhinal cortex and conceptual processing: Effects of feature-based statistics following damage to the anterior temporal lobes.
The perirhinal cortex and conceptual processing: Effects of feature-based statistics following damage to the anterior temporal lobes.
复制标题
DOI：
10.1016/j.neuropsychologia.2015.01.041
复制
发表时间：
2015-09
期刊：
影响因子：
2.6
通讯作者：
Tyler LK
中科院分区：
文献类型：
--
作者：
Wright P;Randall B;Clarke A;Tyler LK
前颞叶（ATL）在语义知识模型中起着重要的作用，尽管还不清楚ATL内的特定子区域如何有助于语义记忆。患有神经退行性疾病（如语义性痴呆）的患者对ATL有广泛的损伤，因此对解剖学和认知之间的关系的推断存在问题。在这里，我们采取一个详细的解剖方法来询问ATL内的子结构有助于概念处理，预测嗅周皮层（PRc）将发挥关键作用的概念，更语义混淆。我们测试了两组患者，PRc受损和未受损，两个行为实验-图片命名和单词图片匹配。对于这两个任务，我们操纵的程度语义混淆的概念。通过对比两组的表现，沿着健康对照，我们发现，PRc的损害导致在两个实验中具有更高的语义混淆性的概念处理性能较差。此外，通过将解剖学定义的感兴趣区域的损伤程度与性能相关联，我们发现PRc损伤与语义易混淆性增加的概念的性能有关。我们的研究结果表明，PRc支持一个必要的和关键的神经认知功能，使细粒度的概念过程发生通过解决语义混淆。我们与损害的ATL分区的概念处理。ATL内PRc的损害与行为表现相关。PRc的损坏导致语义混淆概念的性能变差。PRc支持细粒度语义知识的处理。
The anterior temporal lobe (ATL) plays a prominent role in models of semantic knowledge, although it remains unclear how the specific subregions within the ATL contribute to semantic memory. Patients with neurodegenerative diseases, like semantic dementia, have widespread damage to the ATL thus making inferences about the relationship between anatomy and cognition problematic. Here we take a detailed anatomical approach to ask which substructures within the ATL contribute to conceptual processing, with the prediction that the perirhinal cortex (PRc) will play a critical role for concepts that are more semantically confusable. We tested two patient groups, those with and without damage to the PRc, across two behavioural experiments – picture naming and word–picture matching. For both tasks, we manipulated the degree of semantic confusability of the concepts. By contrasting the performance of the two groups, along with healthy controls, we show that damage to the PRc results in worse performance in processing concepts with higher semantic confusability across both experiments. Further by correlating the degree of damage across anatomically defined regions of interest with performance, we find that PRc damage is related to performance for concepts with increased semantic confusability. Our results show that the PRc supports a necessary and crucial neurocognitve function that enables fine-grained conceptual processes to take place through the resolution of semantic confusability. We relate damage to subregions of the ATL to conceptual processing. Damage to the PRc, within the ATL, correlates with behavioural performance. Damage to PRc results in worse performance for semantically confusable concepts. PRc enables processing of fine-grained semantic knowledge.