Simian immunodeficiency virus-specific T-cell-mediated proliferative response of infected rhesus macaques.
Simian immunodeficiency virus-specific T-cell-mediated proliferative response of infected rhesus macaques.
复制标题
猿猴免疫缺陷病毒特异性 T 细胞介导的感染恒河猴的增殖反应。
DOI：
10.1097/00002030-199003000-00003
复制
发表时间：
1990
期刊：
影响因子：
--
通讯作者：
Gershwin,ME
中科院分区：
文献类型：
--
作者：
McGraw,TP;Vowels,BR;Gardner,MB;Ahmed-Ansari,A;Gershwin,ME
While cell-mediated immunity is known to play an important role in controlling viral infections, its role in human and experimental animal models of human AIDS has not been established. To address this issue, four juvenile rhesus macaques were infected with simian immunodeficiency virus SIV MAC. Freshly isolated peripheral blood mononuclear cells from these SIV MAC-infected macaques and four uninfected control macaques were assessed for T-cell proliferative activity to SIV, monthly, for 10 consecutive months. T cells from SIV-infected monkeys failed to proliferate in response to SIV added directly to the culture. However, when SIV was processed by autologous antigen-presenting cells prior to culture with purified T cells, proliferative responses were uniformly demonstrated in SIV-infected monkeys, but not in uninfected controls. Proliferation in response to heat-inactivated SIV was mediated by CD4+ T cells and was shown to be MHC class II-restricted. However, the proliferative response to infectious SIV was mediated by both CD4+ and CD8+ T cells and was MHC class-restricted. As disease progressed, a decline in the T-cell proliferative response was observed.
