Structure, chromosome mapping and expression of the murine Fgf-6 gene.
Structure, chromosome mapping and expression of the murine Fgf-6 gene.
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发表时间：
1990-06
期刊：
影响因子：
8
通讯作者：
O. Delapeyrière;O. Rosnet;D. Benharroch;F. Raybaud;S. Marchetto;J. Planche;F. Galland;M. Mattei;N. Copeland;N. Jenkins
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作者：
O. Delapeyrière;O. Rosnet;D. Benharroch;F. Raybaud;S. Marchetto;J. Planche;F. Galland;M. Mattei;N. Copeland;N. Jenkins
在小鼠中克隆并分析了成纤维细胞生长因子基因家族的第六个成员。它由三个编码外显子组成，编码198个氨基酸的推定生长蛋白，具有潜在的信号肽，与小鼠Hst/K-fgf和人FGF-6基因产物分别具有79%和93.5%的序列相似性。小鼠Fgf-6基因位于与Int-41基因座不同的区域，属于人类12号染色体和小鼠6号染色体之间保守的连锁群。它具有内在的致癌能力，因为它能够转化培养的成纤维细胞。 Fgf-6 mRNA 水平受发育调节，在妊娠第 15.5 天发育中的胎儿中表达达到峰值，在妊娠晚期和新生儿中表达中等水平。在成人中，可在睾丸、心脏和骨骼肌中检测到 Fgf-6 mRNA。
The sixth member of the fibroblast growth factor gene family was cloned and analysed in the mouse. It is composed of three coding exons and encodes a putative growth protein of 198 amino acids, possessing a potential signal peptide, and presenting 79% and 93.5% sequence similarity with the mouse Hst/K-fgf and human FGF-6 genes products, respectively. The murine Fgf-6 gene is located in a region distinct from the Int-41 locus and belongs to a linkage group conserved between chromosome 12 in man and chromosome 6 in mouse. It presents an intrinsic oncogenic capacity since it is able to transform cultured fibroblasts. Fgf-6 mRNA levels are developmentally regulated with a peak of expression in the developing fetus at day 15.5 of gestation, moderate levels during late gestation and in the neonate. In the adult, Fgf-6 mRNA can be detected in testis, heart and skeletal muscle.