Pulmonary applications of perfluorochemical liquids: ventilation and beyond.
Pulmonary applications of perfluorochemical liquids: ventilation and beyond.
复制标题
DOI：
10.1016/j.prrv.2005.03.010
复制
发表时间：
2005-06-01
影响因子：
5.8
通讯作者：
Shaffer, Thomas H
中科院分区：
文献类型：
--
作者：
Wolfson, Marla R;Shaffer, Thomas H
在液体通气，概念和应用的审查，总结了全氟化学液体的肺部应用。从是否需要这种替代形式的呼吸支持的问题开始，并以从临床试验中吸取的经验教训结束，比较和对比了液体辅助通气的各种方法，提出了肺内全氟化学品液体的机械保护和细胞保护属性的证据，以及替代的肺内应用，包括它们作为药物载体的用途，用于热控制和作为成像剂。
In this review of liquid ventilation, concepts and applications are presented that summarise the pulmonary applications of perfluorochemical liquids. Beginning with the question of whether this alternative form of respiratory support is needed and ending with lessons learned from clinical trials, the various methods of liquid assisted ventilation are compared and contrasted, evidence for mechanoprotective and cytoprotective attributes of intrapulmonary perfluorochemical liquid are presented and alternative intrapulmonary applications, including their use as vehicles for drugs, for thermal control and as imaging agents are presented.