Ca2+ clearance and contractility in vascular smooth muscle: evidence from gene-altered murine models.
Ca2+ clearance and contractility in vascular smooth muscle: evidence from gene-altered murine models.
复制标题
血管平滑肌中的 Ca2+ 清除率和收缩力：来自基因改变的小鼠模型的证据。
DOI：
10.1016/j.yjmcc.2008.05.024
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发表时间：
2008
影响因子：
5
通讯作者：
Paul,RichardJ
中科院分区：
文献类型：
--
作者：
Oloizia,Brian;Paul,RichardJ
钙清除蛋白及其调节剂在心肌收缩力和细胞内Ca 2+浓度（[Ca 2 +]i）调节中的重要性早已确立。确定的关键参与者包括Na+-Ca 2+交换器、Na+-K+ ATP酶、肌质网（内）Ca 2 +-ATP酶和相关的受磷蛋白。基因靶向和转基因小鼠模型在阐明其功能方面至关重要。另一方面，这些蛋白在调节血管平滑肌收缩参数方面的研究较少。最近，基因靶向和转基因模型扩大了我们的知识钙清除蛋白及其作用的紧张性和阶段性平滑肌收缩。在这篇综述中，我们将简要介绍平滑肌中钙离子清除的机制。这些将根据使用基因修饰的小鼠模型的研究来解决，其结果将与心肌细胞中的结果进行比较和对比。最近发现的导致扩张型心肌病的受磷蛋白突变也存在于血管和其他平滑肌中。鉴于这些Ca 2+清除系统对平滑肌调节的重要性，突变也可能导致平滑肌病理学。
The central importance of calcium clearance proteins, and their regulators, in the modulation of myocardial contractility and intracellular Ca2+concentration ([Ca2+]i) has long been established. Key players identified include the Na+–Ca2+exchanger, the Na+–K+ATPase, the sarco(endo)plasmic reticulum Ca2+-ATPase and associated phospholamban. Gene-targeted and transgenic murine models have been critical in the elucidation of their function. The study of these proteins in the regulation of contractile parameters in vascular smooth muscle, on the other hand, is less well studied. More recently, gene-targeted and transgenic models have expanded our knowledge of Ca2+clearance proteins and their role in both tonic and phasic smooth muscle contractility. In this review, we will briefly treat the mechanisms which underlie Ca2+clearance in smooth muscle. These will be addressed in light of studies using gene-modified mouse models, the results of which will be compared and contrasted with those in the cardiomyocyte. The recently identified human mutations in phospholamban, which lead to dilated cardiomyopathy, are also present in vascular and other smooth muscle. Given the importance of these Ca2+clearance systems to modulation of smooth muscle, it is likely that mutations will also lead to smooth muscle pathology.