Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential.
Hemorrhagic fever viruses: Pathogenesis, therapeutics, and emerging and re-emerging potential.
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DOI：
10.3389/fmicb.2022.1040093
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发表时间：
2022
影响因子：
5.2
通讯作者：
Durigon, Edison Luiz
中科院分区：
文献类型：
--
作者：
Florez-Alvarez, Lizdany;de Souza, Edmarcia Elisa;Botosso, Viviane Fongaro;Leal de Oliveira, Danielle Bruna;Ho, Paulo Lee;Taborda, Carlos Pelleschi;Palmisano, Giuseppe;Capurro, Margareth Lara;Rebello Pinho, Joao Renato;Ferreira, Helena Lage;Minoprio, Paola;Arruda, Eurico;de Souza Ferreira, Luis Carlos;Wrenger, Carsten;Durigon, Edison Luiz
关键词：
由于高致命性疾病的出现和重新出现，出血热病毒对全球公共卫生构成威胁。由这些病毒引起的病毒性出血热（VHF）的主要特征是急性发热综合征，伴有凝血异常和全身出血，可能导致危及生命的器官功能障碍。目前，与多器官功能障碍综合征相关的病毒致病性事件仍有待进一步研究。在这篇小综述中，我们讨论了目前对VHF发病机制的认识，并讨论了治疗这些感染的预防和治疗方案的发展。此外，我们还讨论了HFV引起全球紧急情况的可能性沿着有利于它们在原始生态位之外传播的因素。
Hemorrhagic fever viruses (HFVs) pose a threat to global public health owing to the emergence and re-emergence of highly fatal diseases. Viral hemorrhagic fevers (VHFs) caused by these viruses are mostly characterized by an acute febrile syndrome with coagulation abnormalities and generalized hemorrhage that may lead to life-threatening organ dysfunction. Currently, the events underlying the viral pathogenicity associated with multiple organ dysfunction syndrome still underexplored. In this minireview, we address the current knowledge of the mechanisms underlying VHFs pathogenesis and discuss the available development of preventive and therapeutic options to treat these infections. Furthermore, we discuss the potential of HFVs to cause worldwide emergencies along with factors that favor their spread beyond their original niches.
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