KERNICTERUS IN RATS LACKING GLUCURONYL TRANSFERASE .2. FACTORS WHICH ALTER BILIRUBIN CONCENTRATION AND FREQUENCY OF KERNICTERUS
KERNICTERUS IN RATS LACKING GLUCURONYL TRANSFERASE .2. FACTORS WHICH ALTER BILIRUBIN CONCENTRATION AND FREQUENCY OF KERNICTERUS
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DOI：
10.1001/archpedi.1961.04020040050007
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发表时间：
1961-01-01
影响因子：
--
通讯作者：
FIGUEROA, E
中科院分区：
文献类型：
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作者：
JOHNSON, L;SARMIENTO, F;FIGUEROA, E
In the Gunn strain of genetically jaundiced rats, a statistically significant increase in the incidence of kernicterus was found to be associated with increased hyperbilirubinemia, hyproproteinemia, immaturity, poor health, and exposure to increased levels of organic anions. Various exogenous organic anions were tested and found to lower the serum bilirubin of adult rats, and, in young rats, also to increase the kernicterus rate. In addition, intravenous fat emulsions, fatty acids (oleic and [beta]-hydroxybutyric acid), epinephrine and, in fasted rats, heparin, lowered the serum bilirubin in adult rats. These agents were tested because it was postulated that variations in the level of endogenous organic anions (unesterified fatty acids and ketone bodies) might explain the spontaneous increase in kernicterus rate observed during periods of infection and suboptimal nutrition in the rat colony as a whole. Administration of salt-poor albumin to young jaundiced rats decreased the kernicterus rate and increased the levels of serum bilirubin and total protein, all to a significant degree. All of the above facts fit with the hypothesis that variations in kernicterus rate of jaundiced rats are caused not only by variations in the total body bilirubin, but also by variations either in the number of protein binding sites capable of holding bilirubin in the blood stream or the number of endogenous and exogenous substances competing with bilirubin for protein binding sites, or both. Bilirubin can pass the rat placenta, but the fetuses of jaundiced females have only a slight elevated serum bilirubin, perhaps a reflection of their low serum protein levels.
