Exposure to aflatoxins in Japan: risk assessment for aflatoxin B1
Exposure to aflatoxins in Japan: risk assessment for aflatoxin B1
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DOI：
10.1080/19440040903317497
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发表时间：
2010-01-01
影响因子：
2.9
通讯作者：
Kumagai, S.
中科院分区：
文献类型：
--
作者：
Sugita-Konishi, Y.;Sato, T.;Kumagai, S.
根据2004年夏季至2006年冬季为期3年的零售市场调查中24种食品（884个样本）的AFT和AFB 1浓度和频率数据，以及2005年进行的全国健康和营养调查中的食品消费数据，估算了日本食品中总黄曲霉毒素（AFT）和黄曲霉毒素B1（AFB 1）的摄入量。AFT和AFB 1调查显示，在日本，花生、花生制品、可可、巧克力、开心果、白色辣椒、红辣椒、杏仁、薏米、荞麦和玉米粉被认为是AFT（或AFB 1）摄入量的贡献者（AFB 1（AFT）最高水平为0.21至28.0 μ g kg-1（0.21至9.0 μ g kg-1））。使用蒙特卡罗方法的概率方法进行模拟的AFT（或AFB 1）的摄入量分布在日本的每个年龄组的估计。在这项研究中，黄曲霉毒素B1的摄入量范围为0.003至0.004 ng kg-1体重/天（由低至高），而使用联合国粮食及农业组织/世界卫生组织（粮农组织/世卫组织）食品添加剂联合专家委员会（联合专家委员会）设计的公式计算，患癌症的潜在风险估计为0.00004-0.00005人/年/100人，000人，尽管这是在消费者人口的较高水平（第95.0百分位）。结果表明，目前日本膳食中摄入的黄曲霉毒素B1对健康没有明显的影响。
The intake of total aflatoxins (AFT) and aflatoxin B1 (AFB1) from food in Japan was estimated from AFT and AFB1 concentration and frequency data in 24 foods (884 samples) from a 3-year retail market survey from the summer of 2004 to the winter of 2006, and by food consumption data from the National Health and Nutrition Survey performed in 2005. The AFT and AFB1 survey revealed that peanut, peanut products, cocoa, chocolate, pistachio, white pepper, red pepper, almond, job's tears, buckwheat and corn grits are considered to be contributors of AFT (or AFB1) intake in Japan (maximum AFB1 (AFT) levels ranged from 0.21 to 28.0 mu g kg-1 (from 0.21 to 9.0 mu g kg-1)) in AFT-contaminated food. A probabilistic approach using the Monte Carlo method was carried out to simulate an estimate of the AFT (or AFB1) intake distributions in each age group in Japan. In this study, AFB1 intake ranged from 0.003 to 0.004 ng kg-1 body weight day-1 (from lower to upper limits), and the potential risk for cancer using a formula devised by the Joint Food and Agricultural Organization/World Health Organization (FAO/WHO) Expert Committee on Food Additives (JECFA) was estimated at 0.00004-0.00005 person/year/100,000 persons, even though this was in the higher levels (95.0th percentile) of the consumer population. The results suggest that the current dietary intake of AFB1 in Japan has no appreciable effect on health.