Some metabolic effects of a single dose of crystalline dihydrotachysterol.
Some metabolic effects of a single dose of crystalline dihydrotachysterol.
复制标题
单剂量结晶二氢速甾醇的一些代谢影响。
DOI：
10.1139/y72-157
复制
发表时间：
1972
影响因子：
2.1
通讯作者：
J. Little
中科院分区：
文献类型：
--
作者：
R. J. Burriss Garrett;H. Bickley;J. Little
A single 1 mg dose of crystalline dihydrotachysterol was administered by gavage to female rats. Quantitative studies of subsequent changes in serum calcium level, food intake, animal weight, and femur cortical fragility indicated that the effects of this drug were severe and protracted. Serum calcium concentration increased to a peak within 2 days and remained elevated throughout the experiment. Food intake and weight of dihydrotachysterol-treated animals declined severely and a sudden onset of femur cortical fragility was detected on the 5th day following treatment.
