A genome-wide linkage scan for body mass index on Framingham Heart Study families
A genome-wide linkage scan for body mass index on Framingham Heart Study families
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DOI：
10.1186/1471-2156-4-s1-s97
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发表时间：
2003-12-31
期刊：
影响因子：
2.9
通讯作者：
Bergen, AW
中科院分区：
文献类型：
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作者：
Moslehi, R;Goldstein, AM;Bergen, AW
背景：来自社区样本的全基因组扫描数据被用来识别影响体重指数（BMI）的遗传因素。体重指数被定义为体重（公斤）的平方身高（米），其中体重和身高获得的第一次测量之间的年龄为40和50 years.Results：显着的家族相关性，观察到在母亲：父亲（配偶）的相对对，并在所有的相对对检查除了父母：女儿对。单点同胞对回归分析提供了23个标记位点与BMI连锁（p < 0.05）的名义证据。多点同胞对回归分析提供了名义上的证据，连锁BMI在12条染色体上的42个位点。经验的p值显示的结果与多点的结果一致，但三个多点analysis.Conclusion确定的位点也显着：最大的区域，名义上显着的连锁被发现在染色体2，3，和11。通过多点同胞对单性状回归分析，获得了与标记D2S1788、D2S1356、D2S1352、D3S1744和D11S912连锁的最显著证据。我们的研究结果与最近发表的一些使用各种数据集（包括心脏研究数据）的BMI报告一致。
Background: Genome-wide scan data from a community-based sample was used to identify the genetic factors that affect body mass index (BMI). BMI was defined as weight (kg) over the square of height (m), where weight and height were obtained from the first measurement available between the ages of 40 and 50 years.Results: Significant familial correlations were observed in mother: father (spouse) relative pairs and in all relative pairs examined except parent: daughter pairs. Single-point sib-pair regression analysis provided nominal evidence for linkage (p < 0.05) of loci to BMI at 23 markers. Multi-point sib-pair regression analysis provided nominal evidence for linkage to BMI at 42 loci on 12 chromosomes. Empirical p-values showed results consistent with the multi-point results; all but three of the loci identified by multi-point analysis were also significant.Conclusion: The largest regions of nominally significant linkage were found on chromosomes 2, 3, and 11. The most significant evidence for linkage was obtained with markers D2S1788, D2S1356, D2S1352, D3S1744, and D11S912 from multi-point sib-pair single-trait regression analysis. Our results are in agreement with some of the recently published reports on BMI using various data sets including the Framingham Heart Study data.